Results 111 to 120 of about 16,226,702 (331)
Molecular Ecology, 2017 Approximate Bayesian computation (ABC) is a powerful and widely used approach in inference of population history. However, the computational effort required to discriminate among alternative historical scenarios often limits the set that is compared to ...
G. Stone +9 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Ecology and EvolutionLiriodendron was widely distributed across the Northern Hemisphere during the early to middle Miocene, but now is confined to East Asia and North America.
Yanli Cheng +4 more
doaj +1 more source
Evolutionary population history of early Paleoamerican cranial morphology
Science Advances, 2017 Paleoamericans share last common ancestry with modern Native Americans in Asia, suggesting multiple dispersals into the New World. The nature and timing of the peopling of the Americas is a subject of intense debate.
Noreen von Cramon‐Taubadel +2 more
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Mammal diversity survey of Ko Pha-ngan in Surat Thani Province, Thailand [PDF]
ZooKeysThis study aims to survey mammal diversity on Ko Pha-ngan, located 80 km off the east peninsular coast of Surat Thani province, Thailand. Thirteen camera trap sites, 32 transects, six drift line fence traps, five mist net trap sites, and nine live trap ...
Dawn R. Cook-Price +4 more
doaj +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Population History and Gene Divergence in Native Mexicans Inferred from 76 Human Exomes. [PDF]
, 2020 Native American genetic variation remains underrepresented in most catalogs of human genome sequencing data. Previous genotyping efforts have revealed that Mexico's Indigenous population is highly differentiated and substructured, thus potentially ...
Burchard, Esteban G +13 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source