Results 201 to 210 of about 14,560,391 (301)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Re-Evaluating the Population History of Malagasy Native Cattle Reveals Shared African Taurine-Related Ancestry but Distinct Indicine Admixture Histories Relative to East African Cattle. [PDF]

Anim Sci J
Wu J, Endo H, Rakotondraparany F, Ratsoavina FM, Imai K, Yamamoto Y, Shimogiri T, Mannen H, Yonezawa T.   +8 more
europepmc   +1 more source

Correction: Human impact on the recent population history of the elusive European wildcat inferred from whole genome data. [PDF]

BMC Genomics, 2023
Nieto-Blázquez ME, Schreiber D, Mueller SA, Koch K, Nowak C, Pfenninger M.   +5 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The Population History of Domestic Sheep Revealed by Paleogenomes. [PDF]

Mol Biol Evol
Kaptan D, Atağ G, Vural KB, Morell Miranda P, Akbaba A, Yüncü E, Buluktaev A, Abazari MF, Yorulmaz S, Kazancı DD, Küçükakdağ Doğu A, Çakan YG, Özbal R, Gerritsen F, De Cupere B, Duru R, Umurtak G, Arbuckle BS, Baird D, Çevik Ö, Bıçakçı E, Gündem CY, Pişkin E, Hachem L, Canpolat K, Fakhari Z, Ochir-Goryaeva M, Kukanova V, Valipour HR, Hoseinzadeh J, Küçük Baloğlu F, Götherström A, Hadjisterkotis E, Grange T, Geigl EM, Togan İZ, Günther T, Somel M, Özer F.   +38 more
europepmc   +1 more source

Population history, genetic variation, and conservation status of European white elm (Ulmus laevis Pall.) in Poland. [PDF]

Ann For Sci, 2022
Litkowiec M, Chudzińska M, Pasławska A, Pałucka M, Kozioł C, Lewandowski A.   +5 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

The ecological niche and population history shape mosquito population genetics on a group of three Caribbean islands. [PDF]

Parasit Vectors
Helleman P, Schrama M, Trimbos KB, Braks MAH, Schaffner F, Stroo A, Wouters RM, van der Beek JG.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source