Results 211 to 220 of about 2,115,565 (309)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Ancient genomes illuminate Eastern Arabian population history and adaptation against malaria

, 2023
Martiniano R, Haber M, Almarri MA, Mattiangeli V, Kuijpers MCM, Chamel B, Breslin EM, Littleton J, Almahari S, Aloraifi F, Bradley DG, Lombard P, Durbin R.   +12 more
europepmc   +1 more source

Population history and genome wide association studies of birth weight in a native high altitude Ladakhi population. [PDF]

PLoS One, 2022
Bhandari S, Dolma P, Mukerji M, Prasher B, Montgomery H, Kular D, Jain V, Dadhwal V, Williams DJ, Bhattacharyaa A, Gilbert E, Cavalleri GL, Hillman SL.   +12 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Cross-continental transmission and host adaptation of <i>Mycobacterium tuberculosis</i> in China unveiled by population history reconstruction and adaptive evolution signal detection. [PDF]

IMetaOmics
Wu W, Liu Z, Chen H, Tang Y, Jiang Z, Zhang Y, Zhang A, Zhou Z, Marks RS, Zhang F, Yuan H, Yu Y, Mao K, Dinnyés A, Rastogi N, Xie J, Sun Q.   +16 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Genomic insights into the population history of fat-tailed sheep and identification of two mutations that contribute to fat tail adipogenesis. [PDF]

J Adv Res
Jin M, Liu G, Liu E, Wang L, Jiang Y, Zheng Z, Lu J, Lu Z, Ma Y, Liu Y, Quan K, Jin H, Jiang X, Fei X, Li T, Cao J, Yuan Z, Du L, Wang H, Wei C.   +19 more
europepmc   +1 more source

Bifidobacterium Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding. [PDF]

Nutrients, 2022
Taft DH, Lewis ZT, Nguyen N, Ho S, Masarweh C, Dunne-Castagna V, Tancredi DJ, Huda MN, Stephensen CB, Hinde K, von Mutius E, Kirjavainen PV, Dalphin JC, Lauener R, Riedler J, Smilowitz JT, German JB, Morrow AL, Mills DA.   +18 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Ten years of the The Dietary Guidelines for the Brazilian Population: history, science and policy. [PDF]

Epidemiol Serv Saude
Jaime PC, Braga MBL.
europepmc   +1 more source