Results 101 to 110 of about 373,456 (271)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Evolutionary Channels for the Formation of Double Neutron Stars

, 2015
We analyze binary population models of double-neutron stars and compare results to the accurately measured orbital periods and eccentricities of the eight known such systems in our Galaxy.
Andrews, Jeff J., Farr, Will M., Kalogera, Vicky, Willems, Bart   +3 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A Metallicity Catalog of Very Metal-poor Main-sequence Turn-off and Red Giant Stars from LAMOST DR10

The Astrophysical Journal Supplement Series
We present a catalog of 8440 candidate very metal-poor (VMP; [Fe/H] ≤ −2.0) main-sequence turn-off (MSTO) and red giant stars in the Milky Way, identified from low-resolution spectra in LAMOST DR10. More than 7000 of these candidates are brighter than G  
Xiangyu Li, Huiling Chen, Yang Huang, Huawei Zhang, Timothy C. Beers, Linxuan Zhu, Jifeng Liu   +6 more
doaj   +1 more source

A joint 1% calibration of the RR Lyrae and type-II Cepheid Leavitt laws yields homogeneous distances to 93 Galactic globular clusters

Astronomy & Astrophysics
Recent work has established large samples of astrometrically confirmed RR Lyrae and type-II Cepheid members of Galactic globular clusters (GCs). Any given GC can contain multiple such stars at once, notably RR Lyrae stars pulsating in the fundamental ...
Lengen Bastian, Anderson Richard I., Cruz Reyes Mauricio, Viviani Giordano   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

New Perspective on the Multiple-population Phenomenon in Galactic Globular Clusters from a Wide-field Photometric Survey

The Astrophysical Journal
Wide-field photometry of Galactic globular clusters (GCs) has been investigated to overcome limitations from the small field of view of the Hubble Space Telescope in the study of multiple populations.
S. Jang, A. P. Milone, A. F. Marino, M. Tailo, E. Dondoglio, M. V. Legnardi, G. Cordoni, T. Ziliotto, E. P. Lagioia, M. Carlos, A. Mohandasan, E. Bortolan, Y.-W. Lee   +12 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source