Results 1 to 10 of about 215,808 (286)
Population pharmacokinetics [PDF]
Vojnosanitetski Pregled, 2005 Milovanović Jasmina R. +1 more
doaj +6 more sources
Population pharmacokinetics analysis in Lixoft Monolix softwares
Фармакокинетика и Фармакодинамика, 2022 The article has discussed a step-by-step algorithm for developing population pharmacokinetics models in the Lixoft Monolix software. Features of population pharmacokinetics study’s methodology have described.
A. I. Platova
doaj +1 more source
Population Pharmacokinetics of Primaquine in the Korean Population
Pharmaceutics, 2021 While primaquine has long been used for malaria treatment, treatment failure is common. This study aims to develop a population pharmacokinetic model of primaquine and its metabolite, carboxyprimaquine, and examine factors influencing pharmacokinetic ...
Woo-Yul Lee +6 more
doaj +1 more source
Population pharmacokinetics of pomalidomide [PDF]
The Journal of Clinical Pharmacology, 2015 AbstractA population pharmacokinetic (PPK) model of pomalidomide was developed and the influence of demographic and disease‐related covariates on PPK parameters was assessed based on data from 6 clinical trials of pomalidomide (dose range, 0.5–10 mg) in healthy participants (n = 96) and patients with multiple myeloma (MM; n = 144).
Li, Yan +5 more
openaire +2 more sources
Review on Population Pharmacokinetics of Amikacin in Paediatrics
Journal of Pure and Applied Microbiology, 2022 Amikacin is an aminoglycoside antibiotic with a broad-spectrum bacterial coverage that is frequently utilized both as monotherapy and in combination with other antibiotics for severe bacterial infections in the paediatric population.
Keerthana Chandrasekar +4 more
doaj +1 more source
Pharmaceuticals, 2021 Understanding the pharmacokinetics parameter of colistin methanesulfonate sodium (CMS) and colistin is needed to optimize the dosage regimen in critically ill patients. However, there is a scarcity of pharmacokinetics parameters in this population.
Mohd Shafie Zabidi +4 more
doaj +1 more source
Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures [PDF]
Korean Journal of Pediatrics, 2017 PurposeThe aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM.MethodsA retrospective analysis of 18 ...
Jae Won Shin +7 more
doaj +1 more source
Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples [PDF]
, 2015 Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment.
Akkerman, Onno W +6 more
core +7 more sources
Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine During Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania. [PDF]
, 2010 The combination of artemether (ARM) and lumefantrine is currently the first-line treatment of uncomplicated falciparum malaria in mainland Tanzania. While the exposure to lumefantrine has been associated with the probability of adequate clinical and ...
Annerberg, Anna +10 more
core +4 more sources
Pharmaceutics, 2022 Pharmacometrics (PM) and machine learning (ML) are both valuable for drug development to characterize pharmacokinetics (PK) and pharmacodynamics (PD). Pharmacokinetic/pharmacodynamic (PKPD) analysis using PM provides mechanistic insight into biological ...
Lina Keutzer +11 more
doaj +1 more source