Results 21 to 30 of about 215,808 (286)
Population Pharmacokinetics of CC-122
Clinical Pharmacology: Advances and Applications, 2021 Yiming Cheng,1 Jian Chen,2 Michael Pourdehnad,3 Simon Zhou,1 Yan Li1 1Clinical Pharmacology & Pharmacometrics, Bristol Myers Squibb, Summit, NJ, USA; 2Non-Clinical Research & Development, Bristol Myers Squibb, Summit, NJ, USA; 3Early Clinical ...
Cheng Y +4 more
doaj
Frontiers in Pharmacology, 2020 ObjectiveThe purposes of our study were to investigate the population pharmacokinetics of teicoplanin in Chinese children with different renal functions and to propose the appropriate dosing regimen for these pediatric patients.MethodsWe performed a ...
Liuliu Gao +9 more
doaj +1 more source
Population Pharmacokinetics of Daptomycin [PDF]
Antimicrobial Agents and Chemotherapy, 2004 ABSTRACT Data from subjects in nine phase 1 ( n = 153) and six phase 2/3 ( n = 129) clinical trials were combined to identify factors contributing to interindividual variability in daptomycin pharmacokinetics (PK). Over 30 covariates were considered.
Barry, Dvorchik +5 more
openaire +2 more sources
Population Pharmacokinetics of Vancomycin in Pregnant Women
Frontiers in Pharmacology, 2022 Objective: Vancomycin is a glycopeptide antibacterial indicated for serious gram-positive infections. Pharmacokinetics (PK) of vancomycin have not been described in pregnant women.
Rahul K. Goyal +4 more
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DOXYCYCLINE PHARMACOKINETICS IN MAMMALIAN SPECIES OF VETERINARY INTEREST – AN OVERVIEW
Bulgarian Journal of Veterinary Medicine, 2022 Doxycycline is a broad-spectrum tetracycline antibiotic widely used in veterinary medicine. The current review aims to summarise the available data about pharmacokinetics in mammalian species of veterinary interest and to indicate the basic strategies ...
R. Mileva, A. Milanova
doaj +1 more source
Population pharmacokinetics of exenatide [PDF]
British Journal of Clinical Pharmacology, 2016 AimThe aim of the present analysis was to develop a core population pharmacokinetic model for the pharmacokinetic properties of immediate‐release (IR) exenatide, which can be used in subsequent analyses of novel sustained‐release formulations.MethodsData from eight clinical trials, evaluating a wide range of doses and different administration routes ...
Cirincione, Brenda, Mager, Donald E.
openaire +2 more sources
PKPy: a Python-based framework for automated population pharmacokinetic analysis [PDF]
PeerJWe present PKPy, an open-source Python framework designed to automate population pharmacokinetic analysis workflows. The framework emphasizes user accessibility by minimizing the need for manual parameter initialization while maintaining analytical rigor.
Hyunseung Kong +2 more
doaj +2 more sources
Microbiology Spectrum, 2021 Methicillin-resistant Staphylococcus aureus infections are a significant cause of morbidity and mortality in pediatric liver transplant (LT) recipients.
Kensuke Shoji +9 more
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Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant. [PDF]
, 2016 Opioid use in pregnancy has increased dramatically over the past decade. Since prenatal opioid use is associated with numerous obstetrical and neonatal complications, this now has become a major public health problem.
Davis, Jonathan M. +2 more
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The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients
Balkan Journal of Medical Genetics, 2016 The aim of the present study was to investigate the distribution of CYP2C8 variants *3 and *5, as well as their effect on carbamazepine pharmacokinetic properties, in 40 epileptic pediatric patients on carbamazepine treatment.
Milovanovic DD +7 more
doaj +1 more source