Results 161 to 170 of about 2,986,773 (268)

Accelerated Bayesian inference of population size history from recombining sequence data. [PDF]

Nat Genet
Terhorst J.
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Exceedingly low genetic diversity in snow leopards due to persistently small population size. [PDF]

Proc Natl Acad Sci U S A
Solari KA, Morgan S, Poyarkov AD, Weckworth B, Samelius G, Sharma K, Ostrowski S, Ramakrishnan U, Kubanychbekov Z, Kachel S, Johansson Ö, Lkhagvajav P, Hemmingmoore H, Alexandrov DY, Bayaraa M, Grachev A, Korablev MP, Hernandez-Blanco JA, Munkhtsog B, Rosenbaum B, Rozhnov VV, Madad Rajabi A, Noori H, Suryawanshi KR, Armstrong EE, Petrov DA.   +25 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Genomic Evidence of Low Contemporary Effective Population Size and Southern Genetic Reservoirs in an Island Endemic Epiphytic Orchid of Taiwan. [PDF]

Ecol Evol
Chen WY, Sun Y, Wu SP, Huang JP.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Variance of <i>K</i> _s distribution corrects the bias in the divergence caused by the ancestral population size. [PDF]

Front Genet
Li MJ, Li XX, Xu LL, Zhang BW.
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Measuring changes in <i>Plasmodium falciparum</i> census population size in response to sequential malaria control interventions. [PDF]

Elife
Tiedje KE, Zhan Q, Ruybal-Pésantez S, Tonkin-Hill G, He Q, Tan MH, Argyropoulos DC, Deed S, Ghansah A, Bangre O, Oduro AR, Koram KA, Pascual M, Day KP.   +13 more
europepmc   +1 more source