Results 141 to 150 of about 22,269,143 (359)

A Unified Characterization of Population Structure and Relatedness

Genetics, 2016
Many population genetic activities, ranging from evolutionary studies to association mapping, to forensic identification, rely on appropriate estimates of population structure or relatedness.
B. Weir, J. Goudet
semanticscholar   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Sequential Markov coalescent algorithms for population models with demographic structure

, 2009
We analyse sequential Markov coalescent algorithms for populations with demographic structure: for a bottleneck model, a population-divergence model, and for a two-island model with migration.
Mahjani, B., Mehlig, Bernhard,, Eriksson, Anders,   +2 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Genetic Diversity and Connectivity of Brownstripe Red Snapper (Lutjanus vitta) Around Petroleum Platforms and Coastal Areas in the Gulf of Thailand Analyzed by Mitochondrial Control Region Polymorphism

Diversity
Genetic diversity and population connectivity of brownstripe red snapper (Lutjanus vitta) from different petroleum platforms located in the north (N1, N2, N3, and N4), central, and south regions and two coastal locations, Songkhla and Samaesarn (Gulf of ...
Se Songploy, Sirikan Prasertlux, Porntep Punnarak, Tongchai Thitiphuree, Sirithorn Janpoom, Sureerat Tang, Wanwipa Ittarat, Anek Sophon, Sirawut Klinbunga, Bavornlak Khamnamtong, Padermsak Jarayabhand   +10 more
doaj   +1 more source

Spatial patterns of socio-economic structure and change in the Philippines, 1939-60 [PDF]

, 1972
For more about the East-West Center, see http://www.eastwestcenter.org/The present study examines aspects of the uneven spatial distribution of modernization and development within the Philippines over the period 1939-60.
Luna, Telesforo W., East-West Population Institute, Fuchs, Roland J.   +2 more
core  

Population age structure and savings rate impacts on economic growth: evidence from Australia

, 2016
This paper examines the relationship between the dependency ratio, savings rate and real GDP for Australia for the period 1971–2014. Three econometric techniques – dynamic ordinary least squares, fully modified ordinary least squares and the vector ...
Gow, Jeff, Uddin, Gazi A., Alam, Khorshed   +2 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source