Results 121 to 130 of about 22,269,143 (359)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Demographic change and regional competitiveness: The effects of immigration and ageing

, 2007
The demographic profile of a region is usually seen as a slowly changing background phenomenon in the analysis of regional competitiveness and regional growth. However, regional demographic change can have a significant impact on regional competitiveness
Poot, Jacques
core  

Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models.

American Journal of Human Genetics, 2016
Linear mixed models (LMMs) are widely used in genome-wide association studies (GWASs) to account for population structure and relatedness, for both continuous and binary traits.
Han Chen, Chaolong Wang, M. Conomos, A. Stilp, Zilin Li, T. Sofer, Adam A. Szpiro, Wei Chen, John M. Brehm, J. Celedón, S. Redline, G. Papanicolaou, T. Thornton, C. Laurie, K. Rice, Xihong Lin   +15 more
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Large carpenter bees show high dispersal in a tropical semi‐arid region susceptible to desertification

Ecology and Evolution
Desertification is a major threat to biodiversity in arid areas of the world, partly because many organisms in these regions already exist at or near the limits of their movement and physiology.
Sandara N. R. Brasil, Francisca Soares Araujo, Alan Brelsford, Christiana M. A. Faria, Lorenzo R. S. Zanette, S. Hollis Woodard   +5 more
doaj   +1 more source

The population genetic structure of Biomphalaria choanomphala in Lake Victoria, East Africa: implications for schistosomiasis transmission

Parasites & Vectors, 2014
Background The freshwater snail Biomphalaria acts as the intermediate host of Schistosoma mansoni, a globally important human parasite. Understanding the population structure of intermediate host species can elucidate transmission dynamics and assist in ...
Claire J Standley, Sara L Goodacre, Christopher M Wade, J Russell Stothard   +3 more
doaj   +1 more source

Characterizing the Genetic Structure of Populations

, 2007
The ability to characterize the genetic structure of populations continues to be central to all aspects of population and quantitative genetics, and measures based on correlations of pairs of alleles continue to be as relevant now as they were when ...
Chen, Xi
core  

A Structural Analysis of Population Graphs

ArXiv
The format of graphing algorithms for genomic data has been a debate in recent biotechnology. In this paper, we discuss the construction of population graphs using said genomic data. We first examine the GENPOFAD distance measurement, developed by Joly et. al., and prove that this constitutes a metric function.
Ayers, Kimberly, Kooiker, Maxwell
openaire   +4 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Why were New Zealand levels of life-expectation so high at the dawn of the twentieth century?

, 2002
With population ageing becoming an issue of major importance for societies in the developed countries, in both the scientific and policy communities there is widespread interest in the determinants of these structural changes.
Cheung, Jit, Pool, Ian
core