Results 101 to 110 of about 13,097,883 (301)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Population Bulletin, VOL. 75, NO. 1

, 2021
This is an overview of important demographic processes including fertility, mortality, and migration, and their effects on population growth, decline, and composition. The authors describe changes in the geographic distribution of the world’s population,
Mather, Mark, Scommegna, Paola, Jacobsen, Linda A.   +2 more
core  

Plasmodium vivax diversity and population structure across four continents [PDF]

, 2015
Plasmodium vivax is the geographically most widespread human malaria parasite. To analyze patterns of microsatellite diversity and population structure across countries of different transmission intensity, genotyping data from 11 microsatellite markers ...
Barnadas, Céline, Orjuela-Sánchez, P, Erhart, Annette, Carlo Severini (488599), Menard, D, Koepfli, C, Cristian Koepfli, Karunaweera, N, Ratsimbason, Arsène, Tiago Antao, Dionicia Gamboa (123302), van Hong, N, Van den Eede, Peter, Nadira Karunaweera, Céline Barnadas, Ingrid Felger, Karunaweera, Nadira, Menegon, Michela, Priscila T. Rodrigues (762995), Felger, I, Peter Van den Eede, Rodrigues, PT, Antao, T, Michela Menegon, Ratsimbasoa, Arsène, Nour, Bakri, Menard, Didier, Nour, Bakri Y. M., van Hong, Nguyen, Orjuela-Sánchez, Pamela, Barnadas, C, Mueller, I, Rodrigues, Priscila,, Jorge Bendezu (254161), Michela Menegon (762996), Peter Van den Eede (1804675), Rodrigues, Priscila T., Gamboa, Dionicia, Carlo Severini, Bakri Y. M. Nour (488600), Antao, Tiago, Bakri Y M Nour, Ferreira, Marcello U., Ingrid Felger (92160), Erhart, A, Ferreira, Marcelo U., Koepfli, Cristian, Arsène Ratsimbasoa (45054), Didier Menard (2577220), van den Eede, P, Felger, Ingrid, Rodrigues Antao, Tiago, Pamela Orjuela-Sánchez (424204), Céline Barnadas (175150), Didier Menard, Ivo Mueller (46609), Marcelo U. Ferreira (138475), Hong, Nguyen van, Priscila T Rodrigues, Rodrigues, Priscila, T, Gamboa, D, Nour, BYM, Nguyen van Hong, Mueller, Ivo, Tiago Antao (423265), Ivo Mueller, Ferreira, Marcelo, Bendezu, J, Pamela Orjuela-Sánchez, Nadira Karunaweera (762997), Bendezu, Jorge, Annette Erhart, Annette Erhart (80984), Severini, C, Arsène Ratsimbasoa, Rodrigues, Priscilla T., Nguyen van Hong (3243549), Jorge Bendezu, Severini, Carlo, Ratsimbasoa, A, Ferreira, MU, Marcelo U Ferreira, Menegon, M, Dionicia Gamboa, Cristian Koepfli (191306)   +84 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Genome-wide host-associated population structure of

Science in One Health
Background: Scabies, caused by the mite Sarcoptes scabiei , affects more than 200 million people at any one time and can be complicated by severe secondary bacterial disease.
Fang Fang, Pasi K. Korhonen, Siyi Huang, Barbara Moroni, Luca Rossi, Anna R. Molinar Min, Zhijun Hou, Vito Colella, Qingyou Liu, Jacques Guillot, Robin B. Gasser   +10 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Population Briefs, Vol. 6, no. 2 [PDF]

, 2000
IN THIS ISSUE: Incentives help delay marriage among Bangladeshi girls | Trojan horse may offer prostate cancer treatment | Programs for adolescent girls documented in India | What are the links between research and policy?
Population Council
core   +1 more source

Large carpenter bees show high dispersal in a tropical semi‐arid region susceptible to desertification

Ecology and Evolution
Desertification is a major threat to biodiversity in arid areas of the world, partly because many organisms in these regions already exist at or near the limits of their movement and physiology.
Sandara N. R. Brasil, Francisca Soares Araujo, Alan Brelsford, Christiana M. A. Faria, Lorenzo R. S. Zanette, S. Hollis Woodard   +5 more
doaj   +1 more source