Results 91 to 100 of about 5,420,243 (298)

Large carpenter bees show high dispersal in a tropical semi‐arid region susceptible to desertification

Ecology and Evolution
Desertification is a major threat to biodiversity in arid areas of the world, partly because many organisms in these regions already exist at or near the limits of their movement and physiology.
Sandara N. R. Brasil, Francisca Soares Araujo, Alan Brelsford, Christiana M. A. Faria, Lorenzo R. S. Zanette, S. Hollis Woodard   +5 more
doaj   +1 more source

The population genetic structure of Biomphalaria choanomphala in Lake Victoria, East Africa: implications for schistosomiasis transmission

Parasites & Vectors, 2014
Background The freshwater snail Biomphalaria acts as the intermediate host of Schistosoma mansoni, a globally important human parasite. Understanding the population structure of intermediate host species can elucidate transmission dynamics and assist in ...
Claire J Standley, Sara L Goodacre, Christopher M Wade, J Russell Stothard   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Population Genetic Structure and Species Delimitation of a Widespread, Neotropical Dwarf Gecko [PDF]

, 2019
Amazonia harbors the greatest biological diversity on Earth. One trend that spans Amazonian taxa is that most taxonomic groups either exhibit broad geographic ranges or small restricted ranges.
Colli, Guarino R., Gamble, Tony, Higham, Timothy E., Pinto, Brendan J., Russell, Anthony P., Scantlebury, Daniel P., Vitt, Laurie J.   +6 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Spatial Genetic Structure of the Tallgrass Prairie Grass Dichanthelium oligosanthes (Scribner's panicum)

Oklahoma Native Plant Record, 2011
The spatial genetic structure within plant populations and genetic differentiation among populations can vary in strength due to the forces of natural selection, gene flow and genetic drift.
Molly J. Parkhurst, Andrew Doust, Margarita Mauro-Herrera, Janette A. Steets, Jeffrey M. Byrnes   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Genetic variability of two populations of Pseudoplatystoma reticulatum from the Upper Paraguay River Basin

Genetics and Molecular Biology, 2009
Catfishes of the genus Pseudoplatystoma are very important species due to both their high commercial value and their ecological role as voracious predators.
Marcia Matos de Abreu, Luiz Henrique Garcia Pereira, Vilma Barretto Vila, Fausto Foresti, Claudio Oliveira   +4 more
doaj  

Seedling dispersion and population structure of rosewood (Aniba rosaeodora Ducke) in Ucayali, Peru [PDF]

Acta Amazonica
Aniba rosaeodora is a valuable species of the Amazon, being extensively logged to extract linalool - a secondary metabolite that fixes cosmetic perfumes, which has led to its overexploitation and near extinction.
Jorge M. REVILLA-CHÁVEZ, Lyanna H. SÁENZ-RAMÍREZ, Antony C. GONZALES-ALVARADO, Alex J. ALVAREZ-GARCÍA, Jorge A. MORI-VÁSQUEZ, Alexandre M. SEBBENN   +5 more
doaj   +1 more source