Results 131 to 140 of about 22,269,143 (359)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Present and prospective state of policy approaches to fertility
, 1975 For more about the East-West Center, see http://www.eastwestcenter.org/A shortened version of a paper originally prepared for a meeting of the Ford Foundation's international population staff held at Cali, Colombia, Oct.
Saunders, Lyle, Simmons, Ozzie G.
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Oklahoma Native Plant Record, 2011 The spatial genetic structure within plant populations and genetic differentiation among populations can vary in strength due to the forces of natural selection, gene flow and genetic drift.
Molly J. Parkhurst +4 more
doaj +1 more source
Demographic change and transport needs in the Waikato region
, 2005 This report has been commissioned by Environment Waikato (EW) as part of its review of the Land Transport Strategy for the Waikato region. The report identifies key population characteristics that impact on transport needs of the EW region and the ...
Baxendine, Sandra +2 more
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Local PCA Shows How the Effect of Population Structure Differs Along the Genome
Genetics, 2016 Principal component analysis (PCA) is often used to describe overall population structure—patterns of relatedness arising from past demographic history—among a set of genomes. Here, Li and Ralph describe how the patterns uncovered by....
Han Li, Peter L. Ralph
semanticscholar +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Genetics and Molecular Biology, 2009 Catfishes of the genus Pseudoplatystoma are very important species due to both their high commercial value and their ecological role as voracious predators.
Marcia Matos de Abreu +4 more
doaj
Seedling dispersion and population structure of rosewood (Aniba rosaeodora Ducke) in Ucayali, Peru [PDF]
Acta AmazonicaAniba rosaeodora is a valuable species of the Amazon, being extensively logged to extract linalool - a secondary metabolite that fixes cosmetic perfumes, which has led to its overexploitation and near extinction.
Jorge M. REVILLA-CHÁVEZ +5 more
doaj +1 more source
What do Bayesian methods offer population forecasters?
, 2010 The Bayesian approach has a number of attractive properties for probabilistic forecasting. In this paper, we apply Bayesian time series models to obtain future population estimates with uncertainty for England and Wales.
Smith, Peter W.F. +4 more
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