Results 91 to 100 of about 18,981 (229)

The 2.3-Angstrom Structure of Porcine Circovirus 2 [PDF]

Journal of Virology, 2011
ABSTRACT Porcine circovirus 2 (PCV2) is a T=1 nonenveloped icosahedral virus that has had severe impact on the swine industry. Here we report the crystal structure of an N-terminally truncated PCV2 virus-like particle at 2.3-Å resolution, and the cryo-electron microscopy (cryo-EM) image reconstruction of a full-length PCV2 virus-like particle
Reza, Khayat, Nicholas, Brunn, Jeffrey A, Speir, John M, Hardham, Robert G, Ankenbauer, Anette, Schneemann, John E, Johnson   +6 more
openaire   +3 more sources

Establishment and Characterization of an Immortalized Porcine Oral Mucosal Epithelial Cell Line as a Cytopathogenic Model for Porcine Circovirus 2 Infection

Frontiers in Cellular and Infection Microbiology, 2019
Porcine circovirus 2 (PCV2) is a major etiological agent for porcine circovirus-associated diseases and causes enormous economic losses in domestic and overseas swine production.
Hongjie Cui, Wulong Liang, Dahui Wang, Kangkang Guo, Yanming Zhang   +4 more
doaj   +1 more source

ORAL IMMUNOGENICITY OF A PLANT VIRUS VECTOR BASED PORCINE CIRCOVIRUS ANTIGEN [PDF]

, 2013
A recombinant cucumber mosaic virus based expression system has been developed for the production of an immunogenic porcine circovirus epitope. The resulting nanoparticle was shown to elicit specific immune response in mice and pigs, when administered
Balázs, Ervin, Gellért, Ákos, Salánki, Katalin, Tombácz, Kata, Tuboly, Tamás   +4 more
core   +1 more source

A Natural Recombinant NADC30‐Like PRRSV Strain in China: Intersection of CH‐1a, QYYZ, and JXA1 Lineages

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major threat to global swine production. In this study, a novel strain (PRRSV‐AH1) was isolated during a respiratory disease outbreak at a commercial swine operation in Anhui Province, China. Viral replication in MARC‐145 cells was confirmed by observing cytopathic effects (CPEs) and
Heng Zhang, Chengxin Zhang, Yingru Ma, Qin Zhao, Ximei Wang, Qing Pan, Yani Sun, Nan-hua Chen   +7 more
wiley   +1 more source

A Novel In‐Cell ELISA With Superior Sensitivity and Specificity for the Detection of African Swine Fever Virus‐Specific IgM and IgG Antibodies

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
African swine fever (ASF), a high‐profile transboundary animal disease caused by ASF virus (ASFV), imposes a devastating impact on the global swine industry. Given that vaccines are still under development, including field evaluations, early detection of ASFV is crucial for effective disease control and mitigation.
Ping Wu, Aric J. McDaniel, Yelitza Y. Rodríguez, Vivian O’Donnell, Wei Jia, Nan-hua Chen   +5 more
wiley   +1 more source

Attenuation of porcine circovirus type-2b by replacement with the Rep gene of porcine circovirus type-1

Virus Research, 2013
Porcine circovirus type-2 (PCV2) is the primary causative agent of porcine circovirus-associated diseases and has 4 main ORFs, ORF1 (Rep gene), ORF2 (Cap gene), ORF3 within ORF1, and ORF4, which is overlapped with ORF3, and 1 origin (Ori) of replication located between ORF1 and ORF2.
Tao, Hua, Xianwei, Wang, Juan, Bai, Lili, Zhang, Jie, Liu, Ping, Jiang   +5 more
openaire   +2 more sources

Detection of African Swine Fever Virus (ASFV) in Haematopinus suis: Evidence for a Potential New Sylvatic Cycle of ASFV Involving Lice and Domestic Pigs

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
African swine fever (ASF) is a lethal and highly contagious viral disease of domestic and wild pigs, listed as a notifiable disease to the World Organization for Animal Health (WOAH). In the absence of any credible commercially available vaccine, the economic losses to the global pig industry inflicted by ASF is insurmountable.
Tridib Kumar Rajkhowa, Kiran Jayappa, A. Z. Beithatlo, Charitha B. Balakrishna, Laldinliana Khiangte, Guillermo R. Risatti, Nan-hua Chen   +6 more
wiley   +1 more source

Transcriptional Analysis of Porcine Circovirus Type 2

Virology, 2003
Porcine circovirus type 2 (PCV2) is the causative agent of an emerging swine disease, postweaning multisystemic wasting syndrome. In this work, the RNAs of PCV2 synthesized during productive infection in porcine kidney cells were characterized. A total of nine RNAs were detected.
openaire   +2 more sources

Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High‐Throughput Sequencing Data Mining

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Analysis of 57 536 high‐throughput sequencing datasets uncovers a vast, hidden world of viruses in wildlife. The researchers reveal significant geographic and host‐specific patterns of viruses, and their surprising cross‐species transmissions, such as avian flu viruses infecting goats.
Hai Wang, Yafei Meng, Xiaoyuan Chen, Xinyuan Cui, Qian Zuo, Na Han, Xianghui Liang, Xuejuan Shen, Caiwu Li, Desheng Li, Fumin Wang, Liangping He, Rujian Chen, Xingbang Lu, Wenjie You, Aiping Wu, Rui‐Ai Chen, Wu Chen, Chan Ding, Yongyi Shen   +19 more
wiley   +1 more source

Silica Nanoparticles as Multifunctional Platforms for Vaccine Delivery and Immune Modulation in Infectious Diseases

Advanced NanoBiomed Research, Volume 5, Issue 12, December 2025.
Overview of the use of silica nanoparticles in vaccines against pathogens. Different kinds of vaccines against infectious diseases are currently using solid or mesoporous silica nanoparticles in their formulation. Silica microparticles and nanoparticles (SiNPs) have been studied as vehicles for vaccines.
Noe Juvenal Mendoza‐Ramírez, Julio García‐Cordero, Gabriela Navarro‐Tovar, Leticia Cedillo‐Barrón   +3 more
wiley   +1 more source