Results 71 to 80 of about 1,425 (131)
Xenotransplantation, Volume 32, Issue 4, July/August 2025.ABSTRACT Xenotransplantation is becoming an emerging field of interest for the treatment of end‐stage heart disease. In fact, the shortage of human heart donors in European countries requires the increasing investigation of alternative strategies such as heart xenotransplantation.
Nicola Pradegan +6 more
wiley +1 more source
Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley +1 more source
Considering the Risks and Costs of Solid Organ Xenotransplantation
Advanced Biology, Volume 9, Issue 4, April 2025.This perspective discusses the rationale, risks, and costs of whole‐organ xenotransplantation. It considers alternative strategies to obviate the demand for transplants and optimize allotransplantation systems and practices that do not impose xenotransplantation's harms and risks, and whether they are the most ethical and effective means to increase ...
Catharine E. Krebs +5 more
wiley +1 more source
Infectious Subgenomic Amplicon Strategies for Japanese Encephalitis and West Nile Viruses
Journal of Medical Virology, Volume 97, Issue 2, February 2025.ABSTRACT Classical methods for constructing infectious cDNA clones of flaviviruses are often hindered by instability and toxicity. The Infectious‐Subgenomic‐Amplicons (ISA) method is an advancement which utilizes overlapping DNA fragments representing viral genomic sequence and in‐cell recombination to bypass bacterial plasmid assembly.
Prince Pal Singh +2 more
wiley +1 more source
Xenotransplantation, Volume 32, Issue 1, January/February 2025.ABSTRACT Porcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs and can infect human cells in culture. However, no PERV infections have been reported in recipients following preclinical or clinical xenotransplantation or deliberate infection experiments.
Joachim Denner +4 more
wiley +1 more source
Regulation of astrocyte metabolism by mitochondrial translocator protein 18 kDa
Journal of Neurochemistry, Volume 168, Issue 7, Page 1374-1401, July 2024.Astrocytes are key players in maintaining central nervous system (CNS) homeostasis. Proper control of cellular bioenergetics is essential for this, and poor control of astrocyte bioenergetics may underlie many CNS conditions. We hypothesized that translocator protein 18 kDa (TSPO) regulates the metabolism of astrocytes and thus serves as a therapeutic ...
Wyn Firth +7 more
wiley +1 more source
An Approach to Controlling Inflammation and Coagulation in Pig‐to‐Baboon Cardiac Xenotransplantation
Xenotransplantation, Volume 31, Issue 4, July/August 2024.ABSTRACT Introduction Inflammatory responses and coagulation disorders are a relevant challenge for successful cardiac xenotransplantation on its way to the clinic. To cope with this, an effective and clinically practicable anti‐inflammatory and anti‐coagulatory regimen is needed.
Martin Bender +30 more
wiley +1 more source
Virological aspects of non-human primates or swine-to human xenotransplantation [PDF]
, 2018 There are a number of human diseases, which can lead to organ failure. The consequence is often the need for a transplant. The number of performed operations is very low due to the shortage of organs for transplantation.
Hryhorowicz, Magdalena +5 more
core +2 more sources
Field-Based Assessment of the Role of Porcine Cytomegalovirus in Respiratory Disease of Nursery Pigs [PDF]
, 1998 Porcine cytomegalovirus (PCMV) is an ubiquitous infectious agent in swine population throughout the world. Field and some experimental observations have suggested that PCMV plays an important role in causing or enhancing respiratory and/or reproductive ...
Anderson, Matt S. +2 more
core +2 more sources
PathogensTibetan pig is a unique pig breed native to the Qinghai–Tibet Plateau. To investigate viral communities associated with porcine respiratory disease complex (PRDC), 167 respiratory samples were collected from Tibetan pigs in the Ganzi Tibetan autonomous ...
Long Zhou +10 more
doaj +1 more source