Results 61 to 70 of about 807 (120)
Considering the Risks and Costs of Solid Organ Xenotransplantation
Advanced Biology, Volume 9, Issue 4, April 2025.This perspective discusses the rationale, risks, and costs of whole‐organ xenotransplantation. It considers alternative strategies to obviate the demand for transplants and optimize allotransplantation systems and practices that do not impose xenotransplantation's harms and risks, and whether they are the most ethical and effective means to increase ...
Catharine E. Krebs +5 more
wiley +1 more source
Infectious Subgenomic Amplicon Strategies for Japanese Encephalitis and West Nile Viruses
Journal of Medical Virology, Volume 97, Issue 2, February 2025.ABSTRACT Classical methods for constructing infectious cDNA clones of flaviviruses are often hindered by instability and toxicity. The Infectious‐Subgenomic‐Amplicons (ISA) method is an advancement which utilizes overlapping DNA fragments representing viral genomic sequence and in‐cell recombination to bypass bacterial plasmid assembly.
Prince Pal Singh +2 more
wiley +1 more source
Xenotransplantation, Volume 32, Issue 1, January/February 2025.ABSTRACT Porcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs and can infect human cells in culture. However, no PERV infections have been reported in recipients following preclinical or clinical xenotransplantation or deliberate infection experiments.
Joachim Denner +4 more
wiley +1 more source
Regulation of astrocyte metabolism by mitochondrial translocator protein 18 kDa
Journal of Neurochemistry, Volume 168, Issue 7, Page 1374-1401, July 2024.Astrocytes are key players in maintaining central nervous system (CNS) homeostasis. Proper control of cellular bioenergetics is essential for this, and poor control of astrocyte bioenergetics may underlie many CNS conditions. We hypothesized that translocator protein 18 kDa (TSPO) regulates the metabolism of astrocytes and thus serves as a therapeutic ...
Wyn Firth +7 more
wiley +1 more source
An Approach to Controlling Inflammation and Coagulation in Pig‐to‐Baboon Cardiac Xenotransplantation
Xenotransplantation, Volume 31, Issue 4, July/August 2024.ABSTRACT Introduction Inflammatory responses and coagulation disorders are a relevant challenge for successful cardiac xenotransplantation on its way to the clinic. To cope with this, an effective and clinically practicable anti‐inflammatory and anti‐coagulatory regimen is needed.
Martin Bender +30 more
wiley +1 more source
Studies on porcine cytomegalovirus relevant to xenotransplantation. [PDF]
, 2005 Xenotransplantation of porcine organs into humans provides a potential solution to the current shortage of human donor organs, but raises considerable safety concerns including the potential transmission of porcine infectious agents, particularly viruses,
Fryer, J.F.L.
core
PathogensTibetan pig is a unique pig breed native to the Qinghai–Tibet Plateau. To investigate viral communities associated with porcine respiratory disease complex (PRDC), 167 respiratory samples were collected from Tibetan pigs in the Ganzi Tibetan autonomous ...
Long Zhou +10 more
doaj +1 more source
, 2006 The use of porcine organs is being developed as a means to alleviate the shortage of human organs for transplantation. Recommendations have been published for the microbiological specifications of organ-source pigs to reduce the possibility of a ...
Moon, Hyoung-Joon +6 more
core +1 more source
The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation—First Insights
BiomedicinesCardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation.
Martin Bender +23 more
doaj +1 more source