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Absence of interaction between porcine endogenous retrovirus and porcine cytomegalovirus in pig‐to‐baboon renal xenotransplantation in vivo [PDF]
Xenotransplantation, 2018 AbstractBackgroundStudies of xenotransplantation from swine have identified porcine viruses as potential barriers to clinical trials. The biology of these viruses has not been extensively investigated in the in vivo xeno‐environment. Enhancement of viral gene expression by viral and cellular factors acting intranshas been demonstrated for certain ...
Jay A Fishman +2 more
exaly +5 more sources
Regulation of antiviral and antimicrobial innate immunity and immune evasion [PDF]
Cellular and Molecular Life SciencesThe interplay between host innate immunity and pathogen evasion is a dynamic battle shaping infection outcomes. The Topical Collection “Regulation of Antiviral and Antimicrobial Innate Immunity and Immune Evasion” synthesizes findings from thirteen ...
Ling Wang +4 more
doaj +2 more sources
Porcine Lymphotropic Herpesviruses (PLHVs) and Xenotranplantation
Viruses, 2021 Porcine lymphotropic herpesviruses -1, -2 and -3 (PLHV-1, PLHV-2 and PLHV-3) are gammaherpesviruses which are widespread in pigs. They are closely related to the Epstein–Barr virus (EBV) and Kaposi sarcoma herpesvirus, both of which cause severe diseases
Joachim Denner
doaj +1 more source
Virus Safety of Xenotransplantation
Viruses, 2022 The practice of xenotransplantation using pig islet cells or organs is under development to alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or organ failure.
Joachim Denner
doaj +1 more source
Virological Characterization of Pigs with Erythema Multiforme
Microorganisms, 2022 Erythema multiforme in pigs is an acute, self-limiting disease characterized by red skin areas and often associated with anorexia, fever and respiratory problems. The cause of the disease remains unknown.
Sabrina Halecker +5 more
doaj +1 more source
The porcine virome and xenotransplantation
Virology Journal, 2017 The composition of the porcine virome includes viruses that infect pig cells, ancient virus-derived elements including endogenous retroviruses inserted in the pig chromosomes, and bacteriophages that infect a broad array of bacteria that inhabit pigs ...
Joachim Denner
doaj +1 more source
Expression of viral CD45 ligand E3/49K on porcine cells reduces human anti-pig immune responses
Scientific Reports, 2023 Transgenic expression of protective molecules in porcine cells and tissues is a promising approach to prevent xenograft rejection. Viruses have developed various strategies to escape the host’s immune system. We generated porcine B cells (B cell line L23)
Claudia Pokoyski +7 more
doaj +1 more source
Microorganisms, 2021 Minipigs play an important role in biomedical research and have also been used as donor animals in xenotransplantation. To serve as a donor in xenotransplantation, the animals must be free of potential zoonotic viruses, bacteria and parasites.
Sabrina Halecker +5 more
doaj +1 more source
Molecular survey of Cytomegalovirus shedding profile in commercial pig herds in Brazil
Journal of Infection in Developing Countries, 2016 Introduction: Porcine cytomegalovirus (PCMV) causes rhinitis in both young and older pigs. The present study describes the detection and characterization of shedding profiles of PCMV in nine farrow-to-finish Brazilian swine herds.
Maurício Cabral Dutra +9 more
doaj +1 more source
Objective pathogen monitoring in nursery and finisher pigs by monthly laboratory diagnostic testing
Porcine Health Management, 2020 Background Infectious diseases are of great economic importance in commercial pig production, causing both clinical and subclinical disease, with influence on welfare, productivity, and antibiotic use.
Nicole B. Goecke +6 more
doaj +1 more source