Porcine cytomegalovirus: A very unwelcome stowaway. [PDF]
Xenotransplantation, 2022 Mueller NJ.
europepmc +4 more sources
Liver Xenotransplantation: Ethical and Societal Implications. [PDF]
XenotransplantationABSTRACT The shortage of transplantable livers and high waitlist mortality rates have accelerated the clinical translation of liver xenotransplantation. Recent milestones, including extracorporeal perfusion models and gene‐edited pig‐to‐human transplants in both decedents and living patients, indicate that clinical trials may be imminent.
Hurst DJ +4 more
europepmc +2 more sources
Molecular epidemiology of porcine Cytomegalovirus (PCMV) in Sichuan Province, China: 2010-2012. [PDF]
PLoS ONE, 2013 Porcine cytomegalovirus (PCMV) is an immunosuppressive virus that mainly inhibits the immune function of the macrophage and T-cell lymphatic systems, and has caused huge economic losses to the porcine breeding industry.
Xiao Liu +5 more
doaj +2 more sources
First Report of Triple Viral Co-Infection (PPV, PCV2, PCMV) in Wild Boars in the Western Balkans [PDF]
PathogensWild boars are recognized reservoirs of numerous viral pathogens, posing a significant risk to domestic pig populations, particularly in areas with poor biosecurity.
Dimitrije Glišić +6 more
doaj +2 more sources
Genomic evidence of the blood virome and bacteriome provides insights into prevalence, evolution, and susceptibility-related genes across Eurasian pigs [PDF]
BMC GenomicsBackground Infectious diseases are among the primary constraints to pig production, and the globalization of the pig industry has contributed to the emergence and spread of pathogens.
Zhen Liu +6 more
doaj +2 more sources
Commentary: Oral fluid testing can be used to monitor xenotransplant donor herds for porcine cytomegalovirus/roseolovirus status [PDF]
Frontiers in Veterinary ScienceJoachim Denner
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Presence of porcine cytomegalovirus, a porcine roseolovirus, in wild boars in Italy and Germany. [PDF]
Arch Virol, 2023 Abstract Porcine cytomegalovirus (PCMV), a porcine roseolovirus (PRV) that is closely related to human herpesviruses 6 and 7, is commonly found in commercial pigs. PCMV/PRV is important in xenotransplantation, because in preclinical trials in which pig organs were transplanted into non-human primates, transmission of PCMV/PRV was ...
Hansen S +6 more
europepmc +3 more sources
Mining Porcine Blood Whole-DNA Sequencing Datasets to Uncover Pig Viromes: An Exploratory Application to Identify Potential Infecting Agents of an Undefined Disease Outbreak [PDF]
Veterinary SciencesPigs are affected by a variety of pathogenic agents that need to be identified correctly and diagnosed even when co-infections may complicate the application of specific and targeted assays.
Samuele Bovo +6 more
doaj +2 more sources
Regulation of antiviral and antimicrobial innate immunity and immune evasion [PDF]
Cellular and Molecular Life SciencesThe interplay between host innate immunity and pathogen evasion is a dynamic battle shaping infection outcomes. The Topical Collection “Regulation of Antiviral and Antimicrobial Innate Immunity and Immune Evasion” synthesizes findings from thirteen ...
Ling Wang +4 more
doaj +2 more sources
Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival. [PDF]
Sci Rep, 2020 Abstract Xenotransplantation using pig organs has achieved survival times up to 195 days in pig orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an improved immunosuppressive regimen, non-ischaemic preservation with continuous perfusion and control of post-transplantation growth of the transplant,
Denner J +17 more
europepmc +9 more sources