Results 51 to 60 of about 807 (120)

Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation

, 2003
A rapidly progressive disorder termed consumptive coagulopathy (CC) has been observed frequently in pig-to-baboon renal xenotransplantation. CC may be initiated by endothelial activation and induction of procoagulant factors after immunologic injury or ...
Mueller, Nicolas J, Sachs, David H, Qawi, Imrana, Soizic, Daniel, Awwad, Michel, Dor, Frank J M F, Houser, Stuart, Cooper, David K C, Fishman, Jay A, Gollackner, Bernd, Robson, Simon C, Knosalla, Christoph, Buehler, Leo Hans   +12 more
core   +1 more source

Primary human fibroblasts are permissive for porcine cytomegalovirus in vitro

, 2007
Xenotransplantation with pig organs is being considered to alleviate donor organ shortages; however, the risk of introducing porcine viruses to humans is exaggerated in this setting.
Whitteker, Jennifer L
core   +2 more sources

Quantitation of porcine cytomegalovirus in pig tissues by PCR

, 2001
A quantitative-competitive PCR for the quantification of porcine cytomegalovirus (PCMV) was developed. The virus was detected in a variety of pig organs (including potential xenotransplant donations), with viral loads ranging from <10 to 97 genome ...
Paul D. Griffiths, Jay A. Fishman, Vincent C. Emery, Griffiths, Paul D., Fishman, Jay A., Duncan A. Clark, Fryer, Jacqueline F.L., Emery, Vincent C., Jacqueline F. L. Fryer, Clark, Duncan A.   +9 more
core   +1 more source

NMDA‐Type Glutamate Receptor Activation Promotes Ischemic Arrhythmias by Targeting the AKT1–TBX3–Nav1.5 Axis

Acta Physiologica, Volume 241, Issue 9, September 2025.
ABSTRACT Aim The aim of this study is to determine the possible role of N‐methyl‐D‐aspartate receptor (NMDAR) dysregulation in the ischemic electrical remodeling observed in patients with myocardial infarction (MI) and elucidate the underlying mechanisms.
Yuxian He, Han Zhang, Qinggang Zhang, Zewei Sun, Xingang Sun, Ling Xia, Liangrong Zheng, Lihong Wang   +7 more
wiley   +1 more source

Immunosuppressive and Non‐Immunosuppressive Drugs for Heart Xenotransplantation in Humans: Is Europe Ready?

Xenotransplantation, Volume 32, Issue 4, July/August 2025.
ABSTRACT Xenotransplantation is becoming an emerging field of interest for the treatment of end‐stage heart disease. In fact, the shortage of human heart donors in European countries requires the increasing investigation of alternative strategies such as heart xenotransplantation.
Nicola Pradegan, Annamaria Tolomeo, Diego Ciccarelli, Emanuele Cozzi, Antonio Vitiello, Andrea Zovi, Gino Gerosa   +6 more
wiley   +1 more source

Screening for Viruses in Indigenous Greek Black Pigs

Microorganisms
The successful advancement of xenotransplantation has led to the development of highly sensitive detection systems for the screening of potentially zoonotic viruses in donor pigs and preventing their transmission to the recipient.
Hina Jhelum, Vasileios Papatsiros, Georgios Papakonstantinou, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation

, 2004
Tissue-invasive disease due to porcine cytomegalovirus (PCMV) has been demonstrated after pig-to-baboon solid-organ xenotransplantation. Porcine lymphotropic herpesvirus (PLHV)-1 is associated with B cell proliferation and posttransplant ...
Mueller, Nicolas J, Dor, Frank J M F, Cooper, David K C, Sachs, David H, Fishman, Jay A, Gollackner, Bernd, Barth, Rolf N, Livingston, Christine, Knosalla, Christoph, Yamamoto, Shin, Buehler, Leo Hans, Yamada, Kazuhiko   +11 more
core   +1 more source

Active Replication of Porcine Cytomegalovirus (PCMV) Following Transplantation of a Pig Heart into a Baboon despite Undetected Virus in the Donor Pig [PDF]

, 2016
Viral zoonoses may represent a serious problem when xenotransplantation using pig cells, tissues, and organs will be performed. Recently we reported multiorgan failure, mainly liver failure, in a baboon (Papio anubis) after orthotopic transplantation ...
Mayr, Tanja, Morozov, Vladimir A., Reichart, Bruno, Guethoff, Sonja, Denner, Joachim, Abicht, Jan-Michael   +5 more
core   +1 more source

Susceptibility of porcine cytomegalovirus to antiviral drugs

, 2004
Objectives: Re-activation of porcine cytomegalovirus (PCMV) in the xenograft has been reported in pig-to-baboon models of xenotransplantation and is associated with invasive disease and consumptive coagulopathy.
Paul D. Griffiths, Vincent C. Emery, Griffiths, Paul D., Duncan A. Clark, Fryer, Jacqueline F.L., Emery, Vincent C., Jacqueline F. L. Fryer, Clark, Duncan A.   +7 more
core   +1 more source

Clinical Xenotransplantation of Gene‐Edited Pig Organs: A Review of Experiments in Living Humans Since 2022

Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.
Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley   +1 more source