Results 31 to 40 of about 807 (120)

Liver Xenotransplantation: Ethical and Societal Implications. [PDF]

Xenotransplantation
ABSTRACT The shortage of transplantable livers and high waitlist mortality rates have accelerated the clinical translation of liver xenotransplantation. Recent milestones, including extracorporeal perfusion models and gene‐edited pig‐to‐human transplants in both decedents and living patients, indicate that clinical trials may be imminent.
Hurst DJ, Bobier CA, Padilla LA, Merlocco A, Meier RPH.   +4 more
europepmc   +2 more sources

Xenoperfusion-The Transformative Role of Machine Perfusion in Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Recent advances in xenotransplantation have gained substantial public and clinical attention as genetically modified porcine organs are now being transplanted into living human recipients. While only case reports have been published to date, the first clinical trials for kidney xenotransplantation are now ongoing.
Huwyler F, Stoerzer S, Clavien PA, Tibbitt MW.   +3 more
europepmc   +2 more sources

Diversity of respiratory viruses present in nasal swabs under influenza suspicion in respiratory disease cases of weaned pigs

Frontiers in Veterinary Science, 2022
Respiratory diseases in weaned pigs are a common problem, with a complex etiology involving both viruses and bacteria. In the present study, we investigated the presence of eleven viruses in nasal swabs, collected from nurseries (55 cases) under the ...
Gerard E. Martín-Valls, Yanli Li, Ivan Díaz, Esmeralda Cano, Silvana Sosa-Portugal, Enric Mateu, Enric Mateu   +6 more
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival. [PDF]

, 2020
Xenotransplantation using pig organs has achieved survival times up to 195 days in pig orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an improved immunosuppressive regimen, non-ischaemic preservation with ...
Mayr, Tanja, Sorvillo, Nicoletta, Radan, Julia, Luther, Fabian, Mokelke, Maren, Rieben, Robert, Milusev, Anastasia, Brenner, Paolo, Wolf, Eckhard, Reichart, Bruno, Walz, Christoph, Abicht, Jan‑Michael, Längin, Matthias, Fiebig, Uwe, Roshani, Berit, Stahl-Hennig, Christiane, Stahl‑Hennig, Christiane, Krüger, Luise, Denner, Joachim, Abicht, Jan-Michael   +19 more
core   +2 more sources

Virus Safety of Xenotransplantation

Viruses, 2022
The practice of xenotransplantation using pig islet cells or organs is under development to alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or organ failure.
Joachim Denner
doaj   +1 more source

Prevalence of the porcine cytomegalovirus virus (PCMV), a porcine roseolovirus, in wild boars in Italy and Germany

, 2022
Abstract Porcine cytomegalovirus (PCMV), which is a porcine roseolovirus (PRV), closely related to the human herpesviruses 6 and 7, is common among commercial pigs. PCMV/PRV was shown to be important in xenotransplantation because transmission of PCMV/PRV in preclinical trials transplanting pig organs into non-human primates was associated with
Sabrina Hansen, Giovanni Franzo, Maria Luisa Menandro, Ludwig Krabben, Stephen Francis Marino, Benedikt Kaufer, Joachim Denner   +6 more
openaire   +1 more source

Commentary: Oral fluid testing can be used to monitor xenotransplant donor herds for porcine cytomegalovirus/roseolovirus status. [PDF]

Front Vet Sci
To address the shortage of human tissues and organs for treating organ failure, xenotransplantation is progressing toward clinical application. Pigs have been chosen as donor species for various reasons, and extensive genetic modifications are being ...
Denner J.
europepmc   +2 more sources

Virological Characterization of Pigs with Erythema Multiforme

Microorganisms, 2022
Erythema multiforme in pigs is an acute, self-limiting disease characterized by red skin areas and often associated with anorexia, fever and respiratory problems. The cause of the disease remains unknown.
Sabrina Halecker, Vasileios Papatsiros, Dimitra Psalla, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

Presence of porcine cytomegalovirus, a porcine roseolovirus, in wild boars in Italy and Germany [PDF]

, 2023
Porcine cytomegalovirus (PCMV), a porcine roseolovirus (PRV) that is closely related to human herpesviruses 6 and 7, is commonly found in commercial pigs.
SF Marino, S Hansen, G Franzo, Marino, Stephen F., Menandro, Maria Luisa, ML Menandro, B Kaufer, J Denner, Kaufer, Benedikt, Hansen, Sabrina, Franzo, Giovanni, L Krabben, Krabben, Ludwig, Denner, Joachim, Kaufer, Benedikt B.   +14 more
core   +1 more source