Results 31 to 40 of about 1,425 (131)

Pig-to-human kidney xenotransplants using genetically modified minipigs [PDF]

Cell Reports Medicine
Summary: This study develops an observational model to assess kidney function recovery and xenogeneic immune responses in kidney xenotransplants, focusing on gene editing and immunosuppression.
Yi Wang, Gang Chen, Dengke Pan, Hui Guo, Hongtao Jiang, Jianli Wang, Hao Feng, Songzhe He, Jiaxiang Du, Man Zhang, Tao Li, Yong Wang, Hang Yu, Huiling Gan, Quan Wen, Zhian Song, Desheng Li, Yifan Yu, Huanliang Wang, Bing Li, Yong You, Shen Zhou, Mingfa Wang, Lili Liu, Liang Xu, Meng Yang, Hua Pei, Kang Zhang, Zhonghua K. Chen   +28 more
doaj   +2 more sources

The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation—First Insights [PDF]

Biomedicines
Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation.
Martin Bender, Jan-Michael Abicht, Bruno Reichart, Maria Leuschen, Felicia Wall, Julia Radan, Elisabeth Neumann, Maren Mokelke, Ines Buttgereit, Sebastian Michel, Reinhard Ellgass, Katja Gieseke, Stig Steen, Audrius Paskevicius, Joachim Denner, Antonia W. Godehardt, Ralf R. Tönjes, Christian Hagl, David Ayares, Eckhard Wolf, Michael Schmoeckel, Paolo Brenner, Martin B. Müller, Matthias Längin   +23 more
doaj   +3 more sources

Genetically engineered pig heart transplantation in non-human primates [PDF]

Communications Medicine
Background Improvement in gene modifications of donor pigs has led to the prevention of early cardiac xenograft rejection and significantly prolonged cardiac xenograft survival in both heterotopic and orthotopic preclinical non-human primate (NHP) models.
Avneesh K. Singh, Corbin E. Goerlich, Tianshu Zhang, Billeta Lewis, Alena Hershfeld, Gheorghe Braileanu, Kasinath Kurvi, Kathryn Rice, Faith Sentz, Sarah Mudd, Patrick Odonkor, Erik Strauss, Brittney Williams, Allen Burke, Anuj Gupta, Cinthia B. Drachenberg, David Ayares, Bartley P. Griffith, Muhammad M. Mohiuddin   +18 more
doaj   +2 more sources

The First Clinical Renal Xenotransplantation Study (EXPAND): Evaluating Safety, Function, and Zoonotic Risks. [PDF]

Health Care Sci
Health Care Science, Volume 4, Issue 6, Page 377-380, December 2025.
Nashan B.
europepmc   +2 more sources

Porcine Corneal Tissue and Xenozoonotic Risks: A Review of the Current Evidence. [PDF]

Xenotransplantation
ABSTRACT Corneal opacities affect millions worldwide, with corneal transplantation as the primary treatment. However, donor shortages remain a challenge, leaving thousands waiting for transplants. Xenotransplantation using porcine corneas has emerged as a promising alternative due to anatomical and physiological similarities with human corneas ...
Moreira R, Nascimento H, Martins TMDM, Barbieri G, Pires P, Carvalho LN, Rosa LR, Almeida A, Pessuti CL, Ferrer H, Gomes JÁP, Goulart E, Raia S, Belfort R.   +13 more
europepmc   +2 more sources

OMICS Analyses in Xenotransplantation: Initial Findings, Key Precautions, and Virus Infections. [PDF]

Xenotransplantation
ABSTRACT OMICS analyses have the potential to greatly enhance our understanding of rejection and other processes in xenotransplantation. These approaches may therefore contribute to extending the survival time of xenotransplants. Initial OMICS studies in brain‐dead patients following transplantation of pig kidneys or hearts revealed increased ...
Denner J.
europepmc   +2 more sources

Liver Xenotransplantation: Ethical and Societal Implications. [PDF]

Xenotransplantation
ABSTRACT The shortage of transplantable livers and high waitlist mortality rates have accelerated the clinical translation of liver xenotransplantation. Recent milestones, including extracorporeal perfusion models and gene‐edited pig‐to‐human transplants in both decedents and living patients, indicate that clinical trials may be imminent.
Hurst DJ, Bobier CA, Padilla LA, Merlocco A, Meier RPH.   +4 more
europepmc   +2 more sources

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Transcriptome analysis of porcine thymus following porcine cytomegalovirus infection. [PDF]

PLoS ONE, 2014
Porcine cytomegalovirus (PCMV) is a major immunosuppressive virus that mainly affects the immune function of T lymphocytes and macrophages. Despite being widely distributed around the world, no significantly different PCMV serotypes have been found ...
Xiao Liu, Zhiwen Xu, Ling Zhu, Shan Liao, Wanzhu Guo   +4 more
doaj   +1 more source

Examining the potential for porcine-derived islet cells to harbour viral pathogens [PDF]

, 2018
With an onus on safety in the potential use of porcine islet cells as a treatment for diabetes, the use of animals lacking exogenous pathogens is clearly important and multilevel screening strategies have been presented on testing animals and the product.
Crossan, Claire, Gianello, Pierre, Mourad, Nizar, O'Hara, Zoe, Scobie, Linda   +4 more
core   +2 more sources