Results 141 to 150 of about 521,449 (181)

Liver Xenotransplantation: From Early Primate Trials to the First-in-Human Porcine Bridging Therapies. [PDF]

J Clin Med
Nastase AG, Vasilescu AM, Trofin AM, Iftimie NF, Segura-Sampedro JJ, Cadar R, Buzincu I, Davidescu A, Nastase AL, Briceanu OG, Lupascu-Ursulescu C, Lupascu CD.   +11 more
europepmc   +1 more source

Porcine endogenous retrovirus and other viruses in xenotransplantation

Current Opinion in Organ Transplantation, 2009
Potential transmission of zoonotic porcine viruses is a major safety issue in xenotransplantation. This review will first summarize recent studies involving transmission and control of the major concern, porcine endogenous retrovirus (PERV). Second, the potential for zoonotic transfer and safety measures required against other viruses of concern will ...
Scobie, Linda, Takeuchi, Yasuhiro
openaire   +4 more sources

Potential Zoonotic Infection of Porcine Endogenous Retrovirus in Xenotransplantation

, 2012
Porcine endogenous retrovirus (PERV) is considered the major biosafety issue in xenotransplantation. Several techniques have been employed for the analysis of the PERV status in the animal donor and for the assessment of PERV transmission/infection in the xenograft recipient.
Mattiuzzo, Giada, Takeuchi, Yasuhiro, Scobie, Linda   +2 more
openaire   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts

Lancet, The, 1998
The study of whether porcine xenografts can lead to porcine endogenous retrovirus (PERV) infection of recipients is critical for evaluating the safety of pig-to-man xenotransplantation. PERV is carried in the pig germline, and all recipients of porcine tissues or organs will be exposed to the virus.We studied 10 diabetic patients who had received ...
Paul Sandström, Olle Korsgren, Walid Heneine   +2 more
exaly   +3 more sources

Detection of porcine endogenous retrovirus in xenotransplantation

Reproductive Biology, 2014
Xenotransplantation can provide a virtually limitless supply of cells, tissues and organs for a variety of therapeutic procedures. Cells and tissues for use in human transplantation procedures could be supplied using material taken from pigs. However, there is a potential risk of transmission of porcine infectious agents, including porcine endogenous ...
Joanna Gola, Urszula M. Mazurek
openaire   +2 more sources

Porcine endogenous retrovirus – advances, issues and solutions

Xenotransplantation, 2002
No abstract.
Patience, C., Scobie, Linda, Quinn, G.
openaire   +2 more sources

New Insights into Porcine Endogenous Retrovirus (PERV)

2022
Xenotransplantation with porcine organs has been recognized as a promising solution to alleviate the shortage of organs for human transplantation. Porcine endogenous retrovirus (PERV), whose proviral DNAs are buried in the genome of all pig breeds, is a main microbiological risk for xenotransplantation.
yu liu, Yifan Niu, Tao Wang, Dong Niu
openaire   +1 more source

Measurement and Destruction of Porcine Endogenous Retrovirus in the Chinese Bama Minipig

Transplantation Proceedings, 2022
Porcine hepatocytes are widely used in bioartificial liver (BAL) systems for the treatment of liver failure, and Chinese Bama minipigs (BMPs) are extensively used for animal experiments in the field of medicine in China. The genome of porcine endogenous retroviruses (PERVs) has not yet been accurately quantified, posing a threat to their clinical ...
Bingqi Zhang, Mengyu Gao, Wanliu Peng, Shengfu Li, Guangneng Liao, Guang Yang, Ji Bao   +6 more
openaire   +2 more sources

Cellular interaction of functional porcine endogenous retrovirus

Xenotransplantation, 2010
Human cells might display mechanisms counteracting infections by porcine endogenous retroviruses (PERV) in the course of pig‐to‐human xenotransplantation. Mammals have developed a number of protective strategies against viruses, including an intracellular antiretroviral defense as part of the innate immunity.
E. Dörrschuck, M. Krämer, R. R. Tönjes   +2 more
openaire   +1 more source

IN VIVO ANALYSIS OF PORCINE ENDOGENOUS RETROVIRUS EXPRESSION IN TRANSGENIC PIGS

Transplantation, 2001
Xenotransplantation offers a potential solution to the shortage of donor organs for allotransplantation. In vitro studies that demonstrate the transmission of porcine endogenous retroviruses (PERV) from porcine cells to human cells and cell lines have raised concerns regarding the potential transmission of PERV to both xenograft recipients and their ...
G A, Langford, D, Galbraith, A J, Whittam, P, McEwan, X M, Fernández-Suárez, J, Black, A, Shepherd, D, Onions   +7 more
openaire   +2 more sources