Results 151 to 160 of about 521,449 (181)

Presence of Porcine Endogenous Retrovirus C in Domestic Pigs

John Heinrichs Scholarly & Creative Activities Day, 2023
The goal of this study is to create new mutations in the Asymmetric Leaves1 (AS1) gene of Arabidopsis using CRISPR vectors to induce mutations. The intention is to analyze these mutations in order to better understand the structure and function of the AS1 protein in regard to leaf formation.
Avery Welton, null null, null null, null null, null null, null null   +5 more
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Investigation of Porcine Endogenous Retrovirus in the Conservation Population of Ningxiang Pig

Transplantation Proceedings, 2009
Porcine endogenous retrovirus (PERV) varies between pig breeds. Screening and analysis of PERV in putative pig breeds may provide basic parameters to evaluate the biological safety of xenotransplantation from pigs to humans. In this study, PERV was investigated among the conservation population of the Ningxiang pig.
X W, Xing, W J, Hawthorne, S, Yi, D M, Simond, Q, Dong, B, Ye, Q J, Tong, Z, Ye, W, Wang   +8 more
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Repression of porcine endogenous retrovirus infection by human APOBEC3 proteins

Biochemical and Biophysical Research Communications, 2011
It has been shown that porcine endogenous retrovirus (PERV) can infect human cells, indicating that PERV transmission poses a serious concern in pig-to-human xenotransplantation. A number of recent studies have reported on retrovirus interference by antiviral proteins.
Jungeun, Lee, Jae Yoo, Choi, Hee-Jung, Lee, Kang-Chang, Kim, Byeong-Sun, Choi, Yu-Kyoung, Oh, Young Bong, Kim   +6 more
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Is Porcine Endogenous Retrovirus (PERV) Transmission Still Relevant?

Transplantation Proceedings, 2008
Xenotransplantation using porcine cells or organs may be associated with the risk of transmission of zoonotic microorganisms. Porcine endogenous retroviruses (PERVs) pose a potentially high risk because they are integrated into the genome of all pigs and PERV-A and PERV-B at least, which are present in all pigs, can infect human cells.
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A primary screening of porcine endogenous retrovirus in some Chinese pigs

Transplantation Proceedings, 2003
THE CONTINUING shortage of human organs for human transplantation has prompted consideration of animal organs and cells as an alternative tissue source, among which pigs are promising source of xenografts, including fetal pig pancreatic islet cells for insulin-dependent diabetes and neural cells for refractory parkinsonism, as well as extracorporeal ...
L, Zhang, H, Bu, Y, Li, J, Cheng, S, Li, P, Yu   +5 more
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Differential sensitivity of porcine endogenous retrovirus to APOBEC3-mediated inhibition

Archives of Virology, 2015
Pigs are considered to be suitable xenotransplantation organ donors. However, the risk of pathogen transmission from pigs to humans is a major concern in the transplantation of porcine tissues. The porcine endogenous retroviruses (PERVs) PERV-A, PERV-A/C, and PERV-B can infect human cells, but PERV-C is an ecotropic virus infecting only pig cells. Thus,
Sung-Han, Park, Jin Ha, Kim, Yong-Tae, Jung   +2 more
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Detection of porcine endogenous retrovirus in cultures of freshly isolated porcine bone marrow cells

Xenotransplantation, 2003
Abstract: Pigs are under consideration as possible sources of organs for xenotransplantation in humans. The induction of hematopoietic microchimerism through xenotransplantation of source animal hematopoietic cells has been suggested as a means to induce tolerance in potential recipients.
Maritza C, McIntyre, Bhanumathi, Kannan, Gloria I, Solano-Aguilar, Carolyn A, Wilson, Eda T, Bloom, Matiza C, McIntyre   +5 more
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[Research of porcine endogenous retrovirus in Shaziling pigs].

Yi chuan = Hereditas, 2009
To provide basic parameters of evaluating the biological safety of xenotransplantation from pig to human, ear tissues from 31 individuals were randomly collected from a Shazi Ling pig population. PCR and RT-PCR were performed to detect porcine endogenous retrovirus (PERV) proviral DNA and mRNA respectively.
Xiao-Wei, Xing, Li-Qun, Xue, Sheng-Qiang, Huang, Wei, Wang   +3 more
openaire   +1 more source

Large-scale survey of porcine endogenous retrovirus in Chinese miniature pigs

Comparative Immunology, Microbiology and Infectious Diseases, 2008
We conducted a large-scale survey on the existence and expression status of porcine endogenous retrovirus (PERV) in seven breeds of Chinese miniature pigs. Genotyping of PERV was examined by PCR using type-specific primers according to the env genotyping method. The presence and expression status of viral gag, pol and env genes were further analyzed in
Jianmin, Wu, Yuyuan, Ma, Maomin, Lv, Yubiao, Yang, Yanru, Guo, Xiuling, Yu, Kegong, Tian, Jingang, Zhang   +7 more
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[Porcine endogenous retrovirus in Daweizi pigs in Hunan].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2013
To detect porcine endogenous retrovirus (PERV) in Daweizi pigs and to provide basic parameters of evaluating the biological safety for xenotransplantation from pigs to humans.Ear tissues from 42 individuals were randomly collected from a Daweizi pig population. PCR and RT-PCR were performed to detect PERV proviral DNA and mRNA respectively.
Xiao-Wei, Xing, Li-Qun, Xue, Zhao-Hui, Mo, Sheng-Qiang, Huang, Wei, Wang   +4 more
openaire   +1 more source