Results 151 to 160 of about 7,153 (189)
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Porcine endogenous retrovirus – advances, issues and solutions
Xenotransplantation, 2002No abstract.
Patience, C., Scobie, Linda, Quinn, G.
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Detection of porcine endogenous retrovirus in xenotransplantation
Reproductive Biology, 2014Xenotransplantation can provide a virtually limitless supply of cells, tissues and organs for a variety of therapeutic procedures. Cells and tissues for use in human transplantation procedures could be supplied using material taken from pigs. However, there is a potential risk of transmission of porcine infectious agents, including porcine endogenous ...
Joanna, Gola, Urszula, Mazurek
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Porcine endogenous retrovirus and other viruses in xenotransplantation
Current Opinion in Organ Transplantation, 2009Potential transmission of zoonotic porcine viruses is a major safety issue in xenotransplantation. This review will first summarize recent studies involving transmission and control of the major concern, porcine endogenous retrovirus (PERV). Second, the potential for zoonotic transfer and safety measures required against other viruses of concern will ...
Scobie, Linda, Takeuchi, Yasuhiro
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New Insights into Porcine Endogenous Retrovirus (PERV)
2022Xenotransplantation with porcine organs has been recognized as a promising solution to alleviate the shortage of organs for human transplantation. Porcine endogenous retrovirus (PERV), whose proviral DNAs are buried in the genome of all pig breeds, is a main microbiological risk for xenotransplantation.
yu liu, Yifan Niu, Tao Wang, Dong Niu
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Cellular interaction of functional porcine endogenous retrovirus
Xenotransplantation, 2010Human cells might display mechanisms counteracting infections by porcine endogenous retroviruses (PERV) in the course of pig‐to‐human xenotransplantation. Mammals have developed a number of protective strategies against viruses, including an intracellular antiretroviral defense as part of the innate immunity.
E. Dörrschuck +2 more
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Presence of Porcine Endogenous Retrovirus C in Domestic Pigs
John Heinrichs Scholarly & Creative Activities Day, 2023The goal of this study is to create new mutations in the Asymmetric Leaves1 (AS1) gene of Arabidopsis using CRISPR vectors to induce mutations. The intention is to analyze these mutations in order to better understand the structure and function of the AS1 protein in regard to leaf formation.
Avery Welton +5 more
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Potential Zoonotic Infection of Porcine Endogenous Retrovirus in Xenotransplantation
2012Porcine endogenous retrovirus (PERV) is considered the major biosafety issue in xenotransplantation. Several techniques have been employed for the analysis of the PERV status in the animal donor and for the assessment of PERV transmission/infection in the xenograft recipient.
Mattiuzzo, Giada +2 more
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Is Porcine Endogenous Retrovirus (PERV) Transmission Still Relevant?
Transplantation Proceedings, 2008Xenotransplantation using porcine cells or organs may be associated with the risk of transmission of zoonotic microorganisms. Porcine endogenous retroviruses (PERVs) pose a potentially high risk because they are integrated into the genome of all pigs and PERV-A and PERV-B at least, which are present in all pigs, can infect human cells.
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Repression of porcine endogenous retrovirus infection by human APOBEC3 proteins
Biochemical and Biophysical Research Communications, 2011It has been shown that porcine endogenous retrovirus (PERV) can infect human cells, indicating that PERV transmission poses a serious concern in pig-to-human xenotransplantation. A number of recent studies have reported on retrovirus interference by antiviral proteins.
Jungeun, Lee +6 more
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Differential sensitivity of porcine endogenous retrovirus to APOBEC3-mediated inhibition
Archives of Virology, 2015Pigs are considered to be suitable xenotransplantation organ donors. However, the risk of pathogen transmission from pigs to humans is a major concern in the transplantation of porcine tissues. The porcine endogenous retroviruses (PERVs) PERV-A, PERV-A/C, and PERV-B can infect human cells, but PERV-C is an ecotropic virus infecting only pig cells. Thus,
Sung-Han, Park +2 more
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