Results 31 to 40 of about 7,695 (129)

Akkermansia muciniphila enhances chicken resistance to infectious bronchitis virus by boosting GABA synthesis and suppressing the NF‐κB inflammatory pathway

iMetaOmics, Volume 3, Issue 1, March 2026.
Infectious bronchitis virus (IBV) represents a major threat to poultry production, with current control strategies offering limited protection. In this study, we demonstrate gut microbiome is a critical determinant of IBV resistance using fecal microbiota transplantation.
Ouyang Peng, Yufang Liu, Xuanci Wang, Yihui Huang, Yiqin Yang, Qixiang Kang, Rui Geng, Guangli Hu, Aiping Lv, Fangyu Hu, Yongbo Xia, Xin Luo, Jiamin Liao, Yihong He, Zhanpeng Kuang, Yunping Du, Yun Zhang, Chunyi Xue, Zongxi Han, Wen‐Jun Li, Lei Dong, Hao Zhang, Yongchang Cao   +22 more
wiley   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, Volume 15, Issue 8, 23 February 2026.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Tailoring Advanced Metal‐Based Nanomedicines for Adaptable Nanodynamic Disease Therapies and Theranostics

Advanced Materials, Volume 38, Issue 1, 2 January 2026.
This review summarizes recent advances in metal‐based nanomaterials (MBNs) as multifunctional platforms for next‐generation diagnostics and nanodynamic therapies (NDTs), highlighting their structural tunability, diverse therapeutic modalities, and broad biomedical applications in oncology and infectious disease control.
Qihang Ding, Wenhao Li, Ling Mei, Suling Luo, Jing Tao, Chongxiu Shi, Hongping Yang, Wei Feng, Yungchang Chen, Yu Chen, Jong Seung Kim, Xue Shen   +11 more
wiley   +1 more source

Establishment of a Tetra‐Primer ARMS‐PCR Assay to Discriminate Genotypes I and II African Swine Fever Viruses

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The African swine fever virus (ASFV), particularly the genotypes I and II strains that have spread beyond Africa, continues to threaten global swine production and food security. Currently, African swine fever (ASF) control strategies rely heavily on biosecurity measures underpinned with molecular diagnostics.
Leilei Ding, Kun Xue, Tao Ren, Sihan Zhang, Weldu Tesfagaber, Zhenjiang Zhang, Feihu Guan, Jie Zhang, Yuanmao Zhu, Renqiang Liu, Fang Li, Zhigao Bu, Qianyi Zhang, Encheng Sun, Dongming Zhao, Nanhua Chen   +15 more
wiley   +1 more source

Isolation and evolutionary analyses of porcine epidemic diarrhea virus in Asia

PeerJ, 2020
Porcine epidemic diarrhea virus (PEDV) is a leading cause of diarrhea in pigs worldwide. Virus isolation and genetic evolutionary analysis allow investigations into the prevalence of epidemic strains and provide data for the clinical diagnosis and vaccine development.
Liang, Wan, Zhou, Danna, Geng, Chao, Yang, Keli, Duan, Zhengying, Guo, Rui, Liu, Wei, Yuan, Fangyan, Liu, Zewen, Gao, Ting, Zhao, Ling, Yoo, Dongwan, Tian, Yongxiang   +12 more
openaire   +3 more sources

Trypsin-induced hemagglutination activity of porcine epidemic diarrhea virus [PDF]

Archives of Virology, 2010
The hemagglutination (HA) activity of porcine epidemic diarrhea virus (PEDV) was investigated. Two cell-adapted strains of PEDV (KPEDV-9 and SM98LVec) were subjected to HA test against erythrocytes of various origin. Both strains showed HA activity with rabbit erythrocytes only after treatment with trypsin or neuraminidase.
Park, Jung-Eun, Cruz, Deu John M., Shin, Hyun-Jin   +2 more
openaire   +2 more sources

Engineered PCV2 VLPs for Antigen Delivery: A Platform for Next‐Generation Veterinary Vaccines

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The capsid (Cap) protein of porcine circovirus type 2 (PCV2) self‐assembles into virus‐like particles (VLPs) that form stable, noninfectious nanoparticles with T = 1 icosahedral symmetry. Mimicking native virion architecture, these VLPs display antigens in a highly ordered array, conferring strong immunogenicity for both humoral and cellular responses.
Peiyang Ding, Yating Liu, Chenyu Wang, Aiping Wang, Linzhu Ren   +4 more
wiley   +1 more source

A Self‐Amplifying RNA Lipid Nanoparticle (saRNA‐LNP) Vaccine Provides Effective Protection Against Porcine Epidemic Diarrhea

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The development of vaccine platforms capable of inducing sustained, potent, and cost‐effective immunity remains a major challenge in veterinary vaccinology, particularly for coronaviruses, which are often associated with short‐lived vaccine‐induced protection.
Jinqi Shu, Han Zhang, Fang Wang, Hanyu Zhang, Xin Liu, Keshu Liu, Yinhe Zha, Wenqin Chai, Jianghui Yao, Yujun Lin, Chao Wu, Xiaomin Zhao, Jizong Li   +12 more
wiley   +1 more source

Porcine epidemic diarrhea virus: Molecular mechanisms of attenuation and vaccines

Microbial Pathogenesis, 2020
Porcine epidemic diarrhea virus (PEDV) causes an emerging and re-emerging coronavirus disease characterized by vomiting, acute diarrhea, dehydration, and up to 100% mortality in neonatal suckling piglets, leading to huge economic losses in the global swine industry.
Li, Zhiwei, Ma, Zhiqian, Li, Yang, Gao, Sheng, Xiao, Shuqi   +4 more
openaire   +2 more sources

Development of Magnetic Particle–Based Chemiluminescence Immunoassays for Detecting PCV2 VLP‐ and Rep‐Specific Antibodies and Their Combined Use for Immune Evaluation and Replication‐Associated Exposure Assessment

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Porcine circovirus 2 (PCV2) remains a major swine pathogen, and interpretation of capsid protein (Cap)–based serology is challenging in vaccinated populations because vaccine‐induced Cap antibodies overlap with replication‐associated serological signals.
Mingxi Gou, Xiaoqing Song, Jie Fan, Zhixiong Chen, Zihao Kuang, Mengyao Lu, Zhongxin Fan, Meng Ge, Zhong Peng   +8 more
wiley   +1 more source