Results 71 to 80 of about 1,693 (165)

Porcine teschovirus 2 induces an incomplete autophagic responsein PK?15 cells [PDF]

, 2018
Autophagy is a homeostatic process that has been shown to be vital in the innate immune defense against pathogens. However,little is known about the regulatory role of autophagy in porcine teschovirus 2 (PTV-2) replication.
Yuanxing Gu...[et al.]
core  

Evaluation of a fluorogenic real-time reverse transcription-polymerase chain reaction method for the specific detection of all known serotypes of porcine teschoviruses [PDF]

, 2011
Performance of a real-time reverse-transcription polymerase chain reaction method for the rapid, simple and reliable detection of porcine teschovirus (PTV) was assessed.
Cano-Gómez, Cristina, Buitrago, M. D., Fernández-Pinero, Jovita, Mansilla, C., Jovita Fernández-Pinero, Fernández-Pacheco, Paloma, Jiménez-Clavero, Miguel Ángel, Cristina Cano-Gómez, Paloma Fernández-Pacheco, Dolores Buitrago, Carmen Mansilla, Agüero, Montserrat, Montserrat Agüero, Miguel Angel Jiménez-Clavero   +13 more
core   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, Volume 5, Issue 4, August 2025.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

A game of tag: A review of protein tags for the successful detection, purification and fluorescence labelling of proteins expressed in microalgae

The Plant Journal, Volume 122, Issue 6, June 2025.
Significance Statement Protein tags for detection, purification and fluorescence labelling are vital in microalgal research, yet the suitability of specific tags remains largely unexplored. This review discusses the pros and cons of a comprehensive list of protein tags and provides important guidance for experimental design within a microalgal context.
Jonathan Scarfe, Darius Kosmützky, R. Ellen R. Nisbet   +2 more
wiley   +1 more source

Detection of Porcine Teschovirus in Tissues of Experimentally Infected Pigs [PDF]

, 2010
豬鐵士古病毒屬於Picornaviridae病毒科，早期認為是Enterovirus，但之後獨立為Teschovirus病毒屬，目前有11個血清型，其中以PTV-1強毒株於1929年捷克鐵線鎮造成豬隻嚴重腦脊髓灰質炎，致死率高，稱為鐵線病。之後1957年弱毒株於英國他爾番地區豬隻發生，神經症狀輕微，因此稱為他爾番病，目前弱毒株已擴散至全球。台灣於西元2000年九月南投出現首例，且於當年苗栗、嘉義、台中等地區皆有病例報告，截至目前該病毒已普遍存在台灣的豬群。本研究目的為使用免疫組織化學染色法 ...
Lin, Yi-Chien, 林意堅
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Autologous Peripheral Vγ9Vδ2 T Cell Synergizes with αβ T Cell Through Antigen Presentation and BTN3A1 Blockade in Immunotherapy of Cervical Cancer

Advanced Science, Volume 12, Issue 18, May 15, 2025.
This study provides proof‐of‐concept evidence showing that through direct killing, antigen presentation, and competitively binding to BTN3A1, Vγ9Vδ2 T cells amplified from cervical cancer (CC) patients can synergize with αβ T cells to exert anti‐CC function both in vitro and in vivo.
Min Wu, Jian Liu, Liting Liu, Yifan Yang, Hong Liu, Long Yu, Haihong Zeng, Shuo Yuan, Ruiyi Xu, Hangyu Liu, Han Jiang, Shen Qu, Liming Wang, Ying Chen, Jingyu Wang, Yuwei Zhang, Shan He, Ling Feng, Junyan Han, Wanjiang Zeng, Hui Wang, Yafei Huang   +21 more
wiley   +1 more source

Longitudinal Investigation of Brain and Spinal Cord Pericytes After Inducible PDGFRβ+ Cell Ablation in Adult Mice

Journal of Neurochemistry, Volume 169, Issue 3, March 2025.
Pericytes are essential for central nervous system vascular function, yet studying their role in adult pathologies has been challenging due to the scarcity of well‐characterized models that preserve normal vascular development. A tamoxifen‐inducible pericyte ablation model was developed to investigate pericyte dynamics after the acute loss of pericytes.
Dila Atak, Erdost Yıldız, Esra Özkan, Mohammadreza Yousefi, Ayşe Özkan, Aysu Bilge Yılmaz, Ali Burak Kızılırmak, Iman Asaad Alnajjar, Çiçek Kanar, Zeynep Lal Caan, Şakir Ümit Zeybek, Cem İsmail Küçükali, Erdem Tüzün, Yasemin Gürsoy‐Özdemir, Atay Vural   +14 more
wiley   +1 more source

Diagnosis of \u3ci\u3ePorcine teschovirus\u3c/i\u3e encephalomyelitis in the Republic of Haiti [PDF]

, 2012
In February and March 2009, approximately 1,500 backyard pigs of variable age became sick, and approximately 700 of them died or were euthanized in the Lower Artibonite Valley and the Lower Plateau of the Republic of Haiti.
Millien, Max, Corrillo, Consuelo, Moran, Karen, Carrillo, Consuelo, Koster, Leo, White, William, Burrage, Thomas, Pyburn, Dave, Swenson, Sabrina L., Mayr, Gregory, Thomsen, Bruce V., Metwally, Samia, Deng, M. Y., Shaw, John, Fabian, Andrew, Rowland, Jessica, Mohamed, Fawzi, Jacques-Simon, Rodney, Morales, Paula, Jenkins-Moore, Melinda, Barrette, Roger W., McIntosh, Michael T., Deng, Ming Y., Bracht, Alexa J., Flanagan, J. Keith   +24 more
core   +1 more source

Biomimetic Triplet Messenger RNA Formulation in MXene Hydrogel Microneedles for Wound Healing

Aggregate, Volume 6, Issue 2, February 2025.
The current direction in the messenger RNA (mRNA) field is focused on imparting mRNA with competitive synthetic functions and delicating carrier systems. By leveraging advanced artificial intelligence technology, a novel triplet mRNA formulation has been developed and delivered via photothermal‐responsive microneedles for the treatment of diabetic ...
Ji Wang, Yu Wang, Minhui Lu, Xinyue Cao, Ming Xia, Miaoqing Zhao, Yuanjin Zhao   +6 more
wiley   +1 more source

Genome‐wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus

mLife, Volume 4, Issue 1, Page 55-69, February 2025.
Abstract The global dissemination of H5 avian influenza viruses represents a significant threat to both human and animal health. In this study, we conducted a genome‐wide siRNA library screening against the highly pathogenic H5N1 influenza virus, leading us to the identification of 457 cellular cofactors (441 proviral factors and 16 antiviral factors ...
Guangwen Wang, Li Jiang, Jinliang Wang, Qibing Li, Jie Zhang, Fandi Kong, Ya Yan, Yuqin Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Liling Liu, Zhigao Bu, Hualan Chen, Chengjun Li   +15 more
wiley   +1 more source