Results 71 to 80 of about 2,648 (172)

Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation [PDF]

, 2019
Human cytomegalovirus (HCMV) induces a uniquely high frequency of virus-specific effector/memory CD8+ T-cells, a phenomenon termed “memory inflation”.
Abate, Ahmed, Alexandrov, Alexandrov, Arnon, Avdic, Beyranvand Nejad, Brown, Brown, Browne, Chang, Chu, Cloughesy, Cobbs, Dasari, Dekhtiarenko, Del Val, Desjardins, Doisne, Dos Santos, Draper, Duhen, Dziurzynski, Engels, Fiallos, Filley, Fruh, Galluzzi, Gilbert, Gorzer, Harkins, Heemskerk, Howland, Jarry, Johnson, Jutz, Jutz, Kern, Klenerman, Korn, Kotenko, Lauvau, Le, Leisegang, Lim, Lockridge, Locy, Louveau, Lucas, Luo, Malouli, Martikainen, Mitchell, Mocarski, Nair, Neefjes, Odeberg, Overwijk, Pardieck, Polyzoidis, Potter, Prins, Pule, Raftery, Raftery, Raftery, Raftery, Rahman, Ratzinger, Reap, Reardon, Reed, Ressing, Riegler, Rizvi, Rosato, Rosskopf, Sampaio, Sampson, Sandalova, Schempp, Scheper, Schmolke, Schneider, Schonrich, Schub, Sckisel, Shah, Simoni, Sinzger, Soroceanu, Soroceanu, Strang, Stupp, Sturm, Sugawara, Sylwester, Thomas, Tischer, Tran, Trgovcich, Tumeh, van der Burg, van Willigen, Varnum, Vlahovic, Wen, Wills, Yan, Zhao   +109 more
core   +1 more source

A Comprehensive Multiomics Approach Illuminates the Biosynthetic Mechanism of Scoparone in Artemisia capillaris

Plant Biotechnology Journal, Volume 24, Issue 1, Page 346-360, January 2026.
ABSTRACT Artemisia capillaris, a traditional Chinese medicinal plant, has displayed favourable effects in the treatment of jaundice, inflammation of the liver and cholecystitis for thousands of years. However, the biosynthesis of scoparone, the major active component in A. capillaris, remains unclear.
Fuyou Guo, Hong Zhou, Fangfang Yan, Junjie Chen, Qiuyu Zhu, Yu Tan, Yutong Guo, Xiangning Lai, Zongquan Li, Miao Zhang, Yi Ni, Matthana Klakong, Jiamin Yu, Liang Yang, Shili Li, Wei Ding   +15 more
wiley   +1 more source

Metagenomic analysis of the RNA fraction of the fecal virome indicates high diversity in pigs infected by porcine endemic diarrhea virus in the United States

Virology Journal, 2018
Background Emergence and re-emergence of porcine epidemic diarrhea virus (PEDV) in North America, Asia and Europe has caused severe economic loss to the global swine industry.
Qi Chen, Leyi Wang, Ying Zheng, Jianqiang Zhang, Baoqing Guo, Kyoung-Jin Yoon, Phillip C. Gauger, Karen M. Harmon, Rodger G. Main, Ganwu Li   +9 more
doaj   +1 more source

Antigenic and immunogenic properties of industrial strains of Porcine Teschovirus

Agroecological journal, 2015
Досліджено 90 проб матеріалів головного та спинного мозку загиблих або вимушено забитих свиней з клінічними ознаками хвороби Тешена. Виділено 28 ізолятів вірусів. На підставі досліджень біологічних, фізико-хімічних, генетичних, антигенних та імуногенних властивостей штами Porcine teschovirus Дніпровський-34 та Городнянський-31 рекомендовано для ...
openaire   +3 more sources

Unique Characteristics of a Picornavirus Internal Ribosome Entry Site from the Porcine Teschovirus-1 Talfan [PDF]

Journal of Virology, 2002
ABSTRACT The teschoviruses constitute a recently defined picornavirus genus. Most of the genome sequence of the porcine teschovirus-1 (PTV) Talfan and several other strains is known. We now demonstrate that initiation of protein synthesis occurs at nucleotide (nt) 412 on the PTV Talfan RNA and that nt 1 to 405 contains an internal ribosome ...
Kaku, Yoshihiro, Chard, Louisa S., Inoue, Toru, Belsham, Graham J.   +3 more
openaire   +3 more sources

Rationally Designed TadA‐Derived Cytosine Editors Enable Context‐Independent Zebrafish Genome Editing

Advanced Science, Volume 12, Issue 39, October 20, 2025.
A next‐generation cytosine base editor (zTadCBE) and other variants are developed by combining the high‐efficiency (TadCBEa) and low‐indel (TadCBEMax) architectures, followed by the introduction of zebrafish‐optimized mutations (V82S, Q154R) in the TadA domain.
Wei Qin, Sheng‐Jia Lin, Yu Zhang, Kevin Huang, Cassidy Petree, Kevin Boyd, Pratishtha Varshney, Gaurav K. Varshney   +7 more
wiley   +1 more source

Influence of brain-derived neurotrophic factor on pathfinding of dentate granule cell axons, the hippocampal mossy fibers [PDF]

, 2009
Mossy fibers, the dentate granule cell axons, are generated throughout an animal's lifetime. Mossy fiber paths and synapses are primarily restricted to the stratum lucidum within the CA3 region.
Makoto Tamura, Naohiro Tamura, Takamitsu Ikeda, Ryuta Koyama, Yuji Ikegaya, Norio Matsuki, Maki K Yamada   +6 more
core   +2 more sources

Development of a reverse transcription loop-mediated isothermal amplification assay for detection of Porcine teschovirus [PDF]

Journal of Veterinary Diagnostic Investigation, 2011
Loop-mediated isothermal amplification (LAMP) is a sensitive method for DNA amplification. In the present report, the development of a single-tube, one-step, real-time accelerated reverse transcription (RT)-LAMP for the detection of Porcine teschovirus (PTV) is described.
Bin, Wang, Yongqiang, Wang, Zhi-Jun, Tian, Tong-Qing, An, Jin-Mei, Peng, Guang-Zhi, Tong   +5 more
openaire   +2 more sources

Comparative analysis of two newly established Cre rat lines, NeuN‐Cre and Thy1‐Cre, for neurological research

Animal Models and Experimental Medicine, Volume 8, Issue 8, Page 1468-1479, August 2025.
We generated two neuron‐specific Cre rat lines, Thy1‐Cre and NeuN‐Cre, using CRISPR/Cas9‐mediated targeted insertion. Both lines were validated for high neural specificity by crossing them with a Cre reporter rat. When bred with an ND1 conditional knockout rat, the two Cre lines produced distinct phenotypic outcomes. These rat lines have been deposited
Keru Li, Chenyang Liu, Gefan Wan, Lei Zhang, Rui Fan, Xu Zhang, Yuanlong Su, Jiayue He, Ning Liu, Feifei Guan, Wei Dong, Shan Gao, Weining Kong, Xiaolong Qi, Xiaolin Zhang, Yuanwu Ma   +15 more
wiley   +1 more source

Multiple Sclerosis Gene Therapy Using Recombinant Viral Vectors: Overexpression of IL-4, IL-10 and Leukemia Inhibitory Factor in Wharton's Jelly Stem Cells in The EAE Mice Model [PDF]

, 2017
Objective: Immunotherapy and gene therapy play important roles in modern medicine. The aim of this study is to evaluate the overexpression of interleukin-4 (IL-4), IL-10 and leukemia inhibitory factor (LIF) in Wharton's jelly stem cells (WJSCs) in the ...
Abdolhosseinzadeh, Baharak., Akhavan Niaki, Haleh., Alizadeh, Akram., Estiri, Hajar., Fallah, Ali., Farjadfar, Akbar., Ghaderian, Sayyed Mohammad Hossein., Hosseini, Ahmad.   +7 more
core   +1 more source