Results 61 to 70 of about 422,597 (347)

Study on the dynamic evolution of coal pore under variable pressure water injection environment

open access: yesMeitan xuebao
The effects of different water injection pressures and confining pressures on the initial pore structure of coal during the water injection process in coal seams are investigated to improve the application effects of water injection technology in dust ...
Ming YANG   +5 more
doaj   +1 more source

Three Dimensional Seepage Analyses in Mollasadra Dam after Its Impoundments

open access: yesJournal of Applied Sciences and Environmental Management, 2011
Mollasadra dam is an earth fill dam with a clayey core and a height of 72 m from river bed, constructed on Kor River. pore water pressure in the dam was investigated following its construction and first and second impoundments.
GR Rakhshandehroo, M Vaghefi, ARH Zadeh
doaj   +1 more source

Hydraulic Transport Across Hydrophilic and Hydrophobic Nanopores: Flow Experiments with Water and n-Hexane

open access: yes, 2015
We experimentally explore pressure-driven flow of water and n-hexane across nanoporous silica (Vycor glass monoliths with 7 or 10 nm pore diameters, respectively) as a function of temperature and surface functionalization (native and silanized glass ...
Busch, Mark   +4 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Capillary rise dynamics of liquid hydrocarbons in mesoporous silica as explored by gravimetry, optical and neutron imaging: Nano-rheology and determination of pore size distributions from the shape of imbibition fronts

open access: yes, 2015
We present gravimetrical, optical, and neutron imaging measurements of the capillarity-driven infiltration of mesoporous silica glass by hydrocarbons. Square-root-of-time Lucas-Washburn invasion kinetics are found for linear alkanes from n-decane (C10 ...
Egelhaaf, Stefan U.   +4 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Variation of Pore Water Pressure in Tailing Sand under Dynamic Loading

open access: yesShock and Vibration, 2018
Intense vibration affects the pore water pressure in a tailing dam, with the tendency to induce dam liquefaction. In this study, experiments were performed wherein model tailing dams were completely liquefied by sustained horizontal dynamic loading to ...
Jia-xu Jin   +4 more
doaj   +1 more source

Power-free water pump based on a superhydrophobic surface: generation of a mushroom-like jet and anti-gravity long-distance transport [PDF]

open access: yes, 2016
Spontaneous anti-gravitational transportation of liquids across long distances has been widely discovered in nature, such as water transportation from the root to the crown of a tree. However, artificial liquid delivery remains a challenge. In this work,
Carmalt, CJ   +9 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Accumulation of Pore Pressure in a Soft Clay Seabed around a Suction Anchor Subjected to Cyclic Loads

open access: yesJournal of Marine Science and Engineering, 2019
A suction anchor is an appealing anchoring solution for floating production. However, the possible effects of residual pore pressure can be rarely found any report so far in term of the research and design.
Hui Li   +4 more
doaj   +1 more source

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