Results 81 to 90 of about 7,489,349 (254)

Study of the Pore Water Pressure Development Characteristics of PHC Pipe Piles in Soft Soil Foundations

Buildings
When constructing hollow prestressed high-strength concrete (PHC) pipe piles in soft soil foundations, the generation and dissipation of pore water pressure can induce negative friction on the pile.
Zhaolin Jia, Han Wu, Shuaiqi He, Qixiang Zhao, Xiaoxu Zhang   +4 more
doaj   +1 more source

Accumulation of Pore Pressure in a Soft Clay Seabed around a Suction Anchor Subjected to Cyclic Loads

Journal of Marine Science and Engineering, 2019
A suction anchor is an appealing anchoring solution for floating production. However, the possible effects of residual pore pressure can be rarely found any report so far in term of the research and design.
Hui Li, Xuguang Chen, Cun Hu, Shuqing Wang, Jinzhong Liu   +4 more
doaj   +1 more source

Compositional, mechanical and transport properties of carbonate fault rocks and the seismic cycle in limestone terrains: A case study of surface exposures on the Longmenshan Fault, Sichuan, China [PDF]

, 2015
Destructive earthquakes are common in tectonically active regions dominated by carbonate cover rocks. The catastrophic Wenchuan earthquake that struck Sichuan, China, also affected a section of carbonate cover terrain.
Chen, Jianye, CSC: Wenchuan Earthquake: "high angle, thrust earthquake"- requiring high pore pressure, Experimental rock deformation   +2 more
core  

Pore-water squeezing from indurated shales [PDF]

, 2015
High-pressure mechanical squeezing was applied to sample pore waters from a sequence of highly indurated and overconsolidated sedimentary rocks in a drillcore from a deep borehole in NE Switzerland. The rocks are generally rich in clay minerals (28–71 wt.
Wersin, Paul, Oyama, Takahiro, Alt-Epping, Peter, Mazurek, Martin   +3 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Controlling Effects of Residual Deformation on Pore Pressure: A Loess Soil Case

Shock and Vibration, 2019
What the role of each phase medium plays and how their interactions do work should be essential problems to understand dynamic behaviours of soils. In order to disclose interactions between solid, water, and air phases of soils, we applied loess samples ...
Kun Liu, Lanmin Wang, Wentong Tian, Zhenming Wang, Na Li, Yu Sun, Junjie Sun   +6 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Pore Size Effect on Melting Point in Saturated Frozen Soil Systems: A Pressure Perspective at Molecular Scale

Water Resources Research
The melting point depression of water confined in porous media with varying pore sizes has been widely observed. Existing models remain insufficient for describing water phase change in smaller pores (i.e., nano pore), where surface effects become ...
Shuting Ji, Ling Li, Sergio Andres Galindo Torres, Liang Lei   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source