Results 71 to 80 of about 421,042 (302)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Controlling Effects of Residual Deformation on Pore Pressure: A Loess Soil Case

Shock and Vibration, 2019
What the role of each phase medium plays and how their interactions do work should be essential problems to understand dynamic behaviours of soils. In order to disclose interactions between solid, water, and air phases of soils, we applied loess samples ...
Kun Liu, Lanmin Wang, Wentong Tian, Zhenming Wang, Na Li, Yu Sun, Junjie Sun   +6 more
doaj   +1 more source

Numerical Modeling of Pore Water Pressure Development in Mosul Dam [PDF]

Engineering and Technology Journal, 2013
A finite element method is useful tools to be applicable in many geotechnical engineering topics. In this paper the pore water pressure development within the clay core of MOSUL earth dam were investigate considering the saturated/unsaturated conditions ...
Suhail A. A. Khattab, Amina A. Khalil
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Research on landslide displacement prediction method considering pore water pressure

Zhongguo dizhi zaihai yu fangzhi xuebao
Landslide displacement prediction is a critical component of disaster prevention and mitigation. Rainfall infiltration directly affects the distribution of pore water pressure within the landslide mass, and the dynamic variation of pore water pressure ...
Yu QIAN, Li WANG, Bao SHU, Hao XU, Bin CHEN, Tianyu GENG, Hanwen WU   +6 more
doaj   +1 more source

Optimization of a pressurization methodology for extracting pore-water [PDF]

Chemosphere, 2005
Sediment toxicity can be assessed by conducting pore-water toxicity assays with standard water column organisms. Several methods have been developed for sampling pore-water. Centrifugation and pressurization methods are recommended when large volumes of pore-water are required to perform toxicity assays.
Lopes, Isabel, Ribeiro, Rui
openaire   +3 more sources

Power-free water pump based on a superhydrophobic surface: generation of a mushroom-like jet and anti-gravity long-distance transport [PDF]

, 2016
Spontaneous anti-gravitational transportation of liquids across long distances has been widely discovered in nature, such as water transportation from the root to the crown of a tree. However, artificial liquid delivery remains a challenge. In this work,
Carmalt, CJ, Huang, S, Jin, Z, Liu, X, Lu, Y, Lv, C, Parkin, IP, Song, J, Zhao, D, Zheng, H   +9 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Study of the Pore Water Pressure Development Characteristics of PHC Pipe Piles in Soft Soil Foundations

Buildings
When constructing hollow prestressed high-strength concrete (PHC) pipe piles in soft soil foundations, the generation and dissipation of pore water pressure can induce negative friction on the pile.
Zhaolin Jia, Han Wu, Shuaiqi He, Qixiang Zhao, Xiaoxu Zhang   +4 more
doaj   +1 more source

Landslides in sensitive soils, Tauranga, New Zealand. [PDF]

, 2013
In the Tauranga region sensitive soil failures commonly occur after heavy rainfall events, causing considerable infrastructure damage. Several notable landslides include a large failure at Bramley Drive, Omokoroa in 1979, the Ruahihi Canal collapse in ...
Cunningham, Michael J., Jorat, M.E., Lowe, David J., Moon, Vicki G., Morz, T., Wyatt, Justin Burns   +5 more
core   +1 more source