Results 1 to 10 of about 68,379 (226)
The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria [PDF]
Nature Reviews Microbiology, 2008 Gram-negative bacteria are responsible for a large proportion of antibiotic resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm.
Mathias Winterhalter
exaly +2 more sources
Porin-Independent Uptake of Small Molecule Antibiotics Facilitated by Escherichia coli Outer Membrane Vesicles. [PDF]
Biotechnol BioengWe demonstrate that bacterial outer membrane vesicles (OMVs) can enhance antibiotic delivery into Gram‐negative bacteria by bypassing porin‐dependent uptake. Encapsulation of imipenem in OMVs significantly increased its effectiveness against multidrug‐resistant clinical isolates, highlighting OMVs as a promising platform for overcoming permeability ...
Wu M, Harrower RM, Li Z, Brown AC.
europepmc +2 more sources
Antimicrobial Susceptibility Pattern and Mutations of Outer Membrane Porin in Clinical Isolates of Klebsiella pneumoniae [PDF]
مجله علمی دانشگاه علوم پزشکی کردستان, 2022 Background and Aim: Klebsiella pneumoniae is one of the most common causes of community-acquired and nosocomial infections and has acquired numerous resistance mechanisms over time.
Maryam Bayramnezhad +2 more
doaj +2 more sources
Structural-profiling of low molecular weight RNAs by nanopore trapping/translocation using Mycobacterium smegmatis porin A [PDF]
Nature Communications, 2021 Yuqin Wang, Xiaoyu Guan, Shanyu Zhang
exaly +2 more sources
Trials, 2021 Objectives The primary objective of this study is to evaluate the therapeutic potential of hydroxychloroquine (HCQ) in the treatment of adult patients with PCR-confirmed Covid-19 infection in a primary open-care setting, as compared to placebo. The study
Petri J. Vainio +7 more
doaj +1 more source
Molecules, 2021 Here, we investigated general porin regulation in Yersinia pseudotuberculosis 488, the causative agent of Far Eastern scarlet-like fever, in response to sublethal concentrations of antibiotics.
Evgeniya Bystritskaya +5 more
doaj +1 more source
Antibiotics, 2021 Imipenemase-6 (IMP-6) type carbapenemase-producing Enterobacteriaceae is regarded as dangerous due to its unique lack of antimicrobial susceptibility. It is resistant to meropenem (MEPM) but susceptible to imipenem (IPM).
Reo Onishi +10 more
doaj +1 more source
Drosophila Porin/VDAC affects mitochondrial morphology. [PDF]
PLoS ONE, 2010 Voltage-dependent anion channel (VDAC) has been suggested to be a mediator of mitochondrial-dependent cell death induced by Ca(2+) overload, oxidative stress and Bax-Bid activation.
Jeehye Park +6 more
doaj +1 more source
Increased Virulence of Outer Membrane Porin Mutants of Mycobacterium abscessus
Frontiers in Microbiology, 2021 Chronic pulmonary infections caused by non-tuberculous mycobacteria of the Mycobacterium abscessus complex (MABSC) are emerging as a global health problem and pose a threat to susceptible individuals with structural lung disease such as cystic fibrosis ...
Vinicius C. N. de Moura +13 more
doaj +1 more source
Virulence, 2023 Background Mycobacterium abscessus subspecies massiliense (M. massiliense) is increasingly recognized as an emerging bacterial pathogen, particularly in cystic fibrosis (CF) patients and CF centres’ respiratory outbreaks.
Shamira J. Shallom +15 more
doaj +1 more source