Results 31 to 40 of about 78,386 (279)

Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388. [PDF]

, 2020
COR388, a small-molecule lysine-gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease.
Arastu-Kapur, Shirin, Araujo, Joseph, De Lannoy, Ines AM, Dominy, Stephen S, Ermini, Florian, Haditsch, Ursula, Holsinger, Leslie J, Lynch, Casey, Nguyen, Mai, Raha, Debasish, Ryder, Mark I   +10 more
core   +1 more source

Porphyromonas gingivalis Induces RANKL in T-cells [PDF]

Inflammation, 2010
Porphyromonas gingivalis is an oral pathogen highly implicated in chronic periodontitis, a disease characterized by inflammatory destruction of the tooth-supporting alveolar bone and eventually, tooth loss. T-cell innate immune responses are actively involved in this pathological process.
Belibasakis, G N, Bostanci, N, Reddi, D
openaire   +4 more sources

The Effects of Porphyromonas gingivalis on Atherosclerosis-Related Cells

Frontiers in Immunology, 2021
Atherosclerosis (AS), one of the most common types of cardiovascular disease, has initially been attributed to the accumulation of fats and fibrous materials.
Jiaqi Zhang, Mengru Xie, Xiaofei Huang, Guangjin Chen, Yingfu Yin, Xiaofeng Lu, Guang Feng, Ran Yu, Lili Chen   +8 more
semanticscholar   +1 more source

Systemic and Extraradicular Bacterial Translocation in Apical Periodontitis

Frontiers in Cellular and Infection Microbiology, 2021
Apical periodontitis is an inflammatory disease of microbial etiology. It has been suggested that endodontic bacterial DNA might translocate to distant organs via blood vessels, but no studies have been conducted.
María José Bordagaray, María José Bordagaray, Alejandra Fernández, Alejandra Fernández, Mauricio Garrido, Mauricio Garrido, Jessica Astorga, Anilei Hoare, Anilei Hoare, Marcela Hernández, Marcela Hernández   +10 more
doaj   +1 more source

Comparative evaluation of antibacterial efficacy of chlorhexidine mouthwash and Momordica charantia, Spinacia oleracea mouthwash against Streptococcus mutans, Lactobacillus spp., and Porphyromonas gingivalis − An in vitro study

Journal of Orofacial Sciences, 2023
Introduction: Various advances have been made in pharmacology and synthetic organic chemistry, the dependency on natural products, particularly on herbs, remains relatively unchanged.
Krishna S Kadam, Niraj S Gokhale, Shivayogi M Hugar, Neha Kohli, Suneel Dodamani, Shivani Tendulkar   +5 more
doaj   +1 more source

Black-pigmented anaerobic bacteria associated with ovine periodontitis [PDF]

, 2017
Periodontitis is a polymicrobial infectious disease that causes occlusion change, tooth loss, difficulty in rumination, and premature culling of animals.
Borsanelli, Ana C., Busin, Valentina, Dutra, Iveraldo S., Gaetti-Jardim, Elerson, Riggio, Marcello P., Schweitzer, Christiane M., Viora, Lorenzo   +6 more
core   +1 more source

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

Science Advances, 2019
Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors. Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s disease patients.
S. Dominy, Casey C. Lynch, F. Ermini, M. Benedyk, A. Marczyk, A. Konradi, M. Nguyen, Ursula Haditsch, D. Raha, Christina Griffin, L. Holsinger, S. Arastu‐Kapur, S. Kaba, Alexander Lee, M. Ryder, B. Potempa, P. Mydel, A. Hellvard, K. Adamowicz, H. Hasturk, G. Walker, E. Reynolds, R. Faull, M. Curtis, M. Dragunow, J. Potempa   +25 more
semanticscholar   +1 more source

PERBEDAAN EFEKTIVITAS CHLORHEXIDINE GLUKONAT 0,2% DENGAN TEH HIJAU (CAMELLIA SINENSIS) TERHADAP JUMLAH PORPHYROMONAS GINGIVALIS

ODONTO: Dental Journal, 2017
Background: Periodontitis is a periodontal inflammation caused by plaque that contains pathogens, Porphyromonas gingivalis is one of them. Chlorhexidine therapy used to reduce the number of pathogenic bacteria causing periodontitis.
Devi Dwipriastuti, R. Rama Putranto, Welly Anggarani   +2 more
doaj   +1 more source

The Porphyromonas gingivalis hemagglutinins HagB and HagC are major mediators of adhesion and biofilm formation [PDF]

, 2016
Porphyromonas gingivalis is a bacterium associated with chronic periodontitis that possesses a family of genes encoding hemagglutinins required for heme acquisition.
Connolly, E., Culshaw, S., Doyle, R., Millhouse, E., Moran, G.P., Ramage, G.   +5 more
core   +1 more source

Genetic exchange and reassignment in Porphyromonas gingivalis [PDF]

Journal of Oral Microbiology, 2018
Porphyromonas gingivalis is considered a keystone pathogen in adult periodontitis but has also been associated with systemic diseases. It has a myriad of virulence factors that differ between strains. Genetic exchange and intracellular genome rearrangements may be responsible for the variability in the virulence of P. gingivalis.
Olsen, Ingar, Chen, Tsute, Tribble, Gena D   +2 more
openaire   +6 more sources