Results 81 to 90 of about 56,408 (287)

BMAL1-Downregulation Aggravates Porphyromonas Gingivalis-Induced Atherosclerosis by Encouraging Oxidative Stress

Circulation Research, 2020
Supplemental Digital Content is available in the text. Rationale: Atherosclerotic cardiovascular diseases are the leading cause of mortality worldwide. Atherosclerotic cardiovascular diseases are considered as chronic inflammation processes.
Mengru Xie, Q. Tang, Jiaming Nie, Chao Zhang, Xin Zhou, Shaoling Yu, Jiwei Sun, Xiang Cheng, N. Dong, Yu Hu, Lili Chen   +10 more
semanticscholar   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line

Frontiers in Microbiology, 2016
Periodontal disease represents a group of oral inflammatory infections initiated by oral pathogens which exist as a complex biofilms on the tooth surface and cause destruction to tooth supporting tissues. The severity of this disease ranges from mild and
K. How, K. Song, Kok-Gan Chan
semanticscholar   +1 more source

Immune Evasion Strategies of Porphyromonas gingivalis [PDF]

Journal of Oral Biosciences, 2011
Porphyromonas gingivalis is strongly correlated with chronic periodontitis. Its chronic persistence in the periodontium depends on its ability to evade host immunity without inhibiting the overall inflammatory response, which is actually beneficial for this and other periodontal bacteria.
openaire   +2 more sources

Stress response of Porphyromonas gingivalis [PDF]

Oral Microbiology and Immunology, 1994
The heat shock response of Porphyromonas gingivalis was examined by 1 ‐ and 2‐dimensional polyacrylamide gel electrophoresis after metabolic labeling with [14C]‐amino acids. When P. gingivalis cells were shifted from 37° C to 42° C, elevated synthesis of 4 proteins with the apparent molecular weight of 92, 80, 74, and 62 kDa was observed, and synthesis
B, Lu, B C, McBride
openaire   +2 more sources

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Effect Virgin Coconut Oil On Porphyromonas Gingivitis, Staphylococcus Aureus Bacteria

International Dental Journal
Aim or purpose: Study aims to determine the efficacy of Virgin Coconut Oil in inhibiting bacterial growth. Porphyromonas gingivalis and Staphylococcus aureus as bacterial agents of periodontal disease Materials and methods: This research employs an ...
Hasanuddin Thahir, Nurul Azizah, Andi Keisha Faradiza Nawir   +2 more
doaj   +1 more source

Development of antiseptic adaptation and cross-adapatation in selected oral pathogens in vitro [PDF]

, 2019
There is evidence that pathogenic bacteria can adapt to antiseptics upon repeated exposure. More alarming is the concomitant increase in antibiotic resistance that has been described for some pathogens.
Bernaerts, Kristel, Boon, Nico, Herrero, Esteban Rodriguez, Khodaparast, Ladan, Khodaparast, Laleh, Quirynen, Marc, Teughels, Wim, Verspecht, Tim   +7 more
core   +2 more sources

Porphyromonas gingivalis Outer Membrane Vesicles Increase Vascular Permeability

Journal of dentistry research, 2020
Periodontitis is increasingly associated with increased risk of cardiovascular and other systemic diseases. The Gram-negative anaerobe, Porphyromonas gingivalis, is a key periodontal pathogen, and several lines of evidence link the presence of this ...
Cher Farrugia, Graham P. Stafford, Craig Murdoch   +2 more
semanticscholar   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source