Results 61 to 70 of about 19,346 (250)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Factors Influencing Organisational Commitment and Adaptive Work Behaviour of the Digital Native Employees in Broadcasting Stations in Delta State, Nigeria

Ianna Journal of Interdisciplinary Studies, 2023
Background: Employees from different generations differ in their habits, drives, and attitudes. Miscommunication, difficulty retaining top talent, high employee attrition, work-life conflict, and a decline in organisational loyalty are possible ...
Onofere Princewill Okereka, Abraham Ejogba Orhero, Ugo Chuks Okolie   +2 more
doaj   +2 more sources

Creating a Positive Personal Leadership Brand Framework: A Positive Organisational Behaviour Perspective

Southern African Business Review
Background: There is a clear global need for leadership that positively impacts both the organisation and employees. This study proposes that business leaders with a positive personal brand may influence followers’ perceptions and contribute to a positive organisational brand image.
Shallaine Padayachee, Sanchen Henning, Mthokozisi Mpofu   +2 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Exploring the Intersections of Artificial Intelligence, Organizational Behavior, and Communication Dynamics in the Modern Workplace

International Journal of Management, Knowledge and Learning
Purpose: While organisations struggle to improve efficiency and productivity, the interaction between AI, organisational behaviour, and communication dynamics tends to be complex in the rapidly evolving modern workplace.
Ioseb Gabelaia, Ramunė Bagočiūnaitė, Viktorija Navickienė   +2 more
doaj   +1 more source

Examining the Moderating Role of Phubbing in the Impact of Workplace Incivility on Organisational Ostracism [PDF]

Interdisciplinary Description of Complex Systems
The study examining the moderating role of phubbing in the impact of workplace incivility on organisational ostracism was conducted with a sample of 423 employees.
Mehmet Ali Canbolat, Esra Yildiz, Morena Paulišić   +2 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Perspectives of female leaders on sense of coherence and mental health in an engineering environment

SA Journal of Industrial Psychology, 2013
Orientation: Positive organisational behaviour impacts strongly on various individual and work-related outcomes. Gender perspectives in this paradigm have not yet been comprehensively researched.
Claude-Hélène Mayer, Llewellyn E. Van Zyl   +1 more
doaj   +1 more source