Results 71 to 80 of about 19,346 (250)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Examining the relationship between internet addiction, psychological resilience, social isolation and organisational citizenship behaviour

ROL Spor Bilimleri Dergisi
The purpose of this study is to examine the relationships between internet addiction, social isolation, psychological resilience and organisational citizenship behaviour in physical education teachers.
Selman Cutuk, Fikret Soyer
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

EXPLORING SATISFACTION WITH INTERNAL COMMUNICATION [PDF]

Hum, 2015
Communication and especially its internal component represent a key precondition for a successful organisational functioning. Internal communication can be defined as a system of all managing communication activities which influence on employees ...
Nino Ćorić, Ilija Musa
doaj  

Proactive behaviour towards strength use and deficit improvement, hope and efficacy as predictors of life satisfaction amongst first-year university students

SA Journal of Industrial Psychology, 2015
Orientation: The orientation of this study is towards proactive behaviour towards strength use (PBSU) and proactive behaviour towards deficit improvement (PBDI) and their relationship with hope, efficacy and life satisfaction of first-year university ...
Frederick W. Stander, Elsabe Diedericks, Karina Mostert, Leon T. de Beer   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Test of a causal Human Resource Management-Performance Linkage Model: Evidence from the Greek manufacturing sector [PDF]

International Journal of Business Science and Applied Management, 2011
Although a number of studies have recognized the relationship between Human Resource Management (HRM) policies and organisational performance, the mechanisms through which HRM policies lead to organisational performance remain still unexplored.
Katou, A., Katou, A.
doaj  

Psychological capital, work engagement and organisational commitment amongst call centre employees in South Africa

SA Journal of Industrial Psychology, 2013
Orientation: The development of psychological capital amongst call centre employees could have an impact on positive work-related attitudes and behaviour; such as work engagement and organisational commitment.
Janet C. Simons, Johanna H. Buitendach
doaj   +1 more source

The dynamics of collaborative behaviour based on seating position in islamic education organisations

At Turots: Jurnal Pendidikan Islam
Seating arrangements are often made in organisations. Seating changes can occur due to changes in organisational structure or room construction. The research aims to explore in depth how seating positions in the workspace shape and influence the dynamics of collaboration among members of an educational organization.
Gunarti Ika Pradewi, null M. Abidin Arkham, null Wahyuadi Nugroho, null Nayla Anriana Riswari, null Nurul Hidayah, null Bayu Edi Nugroho   +5 more
openaire   +1 more source