Results 61 to 70 of about 79,172 (282)

Towards a semantic typology of specific determiners [PDF]

open access: yes, 2017
This paper investigates properties of a class of determiners which can be loosely la- belled specific in that their distribution falls in between maximally-quantifying definite determiners and indefinites which only contribute existential quantification.
Simonenko, Alexandra
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Scrambling and reference in german [PDF]

open access: yes, 2013
Although the linear order of arguments (and adverbials) in German is relatively free, it underlies certain restrictions; these don’t apply to the so-called unmarked order for arguments (Lenerz 1977) and adverbials (Frey/Pittner 1998).
Lenerz, Jürgen
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

MIXED METHOD: STUDENTS’ ABILITY IN APPLYING POSSESSIVE PRONOUN IN WRITING SENTENCES AT THE 1ST SEMESTER FKIP UNILAK PEKANBARU

open access: yesLectura: Jurnal Pendidikan, 2017
As the students of English Department, the students should be able in doing grammarwell, in this case Possessive Pronoun. The purpose of this research was to find out the students’ability in applying Possessive Pronoun and their common problem in ...
Syahdan Syahdan
doaj  

La expansión del posesivo pospuesto a la luz de documentación navarra (y aragonesa) del siglo XIII

open access: yesScripta: Revista Internacional de Literatura i Cultura Medieval i Moderna, 2016
En los primitivos documentos romances el posesivo sólo aparece antepuesto al sustantivo (“(el) nuestro padre”). La posposición (“padre nuestro”) se empieza a registrar en el siglo XIII en aragonés y en dialecto navarro.
Ángeles Romero Cambrón
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Observations on non-possessive usages of personal markers (possessive suffixes) in Nganasan

open access: yesEesti ja Soome-ugri Keeleteaduse Ajakiri, 2015
This paper aims at a systematic overview of the non-possessive usages of possessive (relational) suffixes in Nganasan. In the analyzed corpus, the non-anchoring usage types of the 3rd person suffix (including the direct anaphoric and situational usages),
Réka Zayzon
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

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