Results 131 to 140 of about 95,371 (247)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Effects of Traditional and Velocity-Based Designed Post Activation Performance Enhancement Interventions on Agility Performance

International Journal of Disabilities Sports and Health Sciences
The aim of the study was to examine the effects of post-activation performance enhancement interventions designed with traditional strength training and velocity-based training on agility performance. The study was completed in three experimental sessions with 20 male participants (age;18.10±0.71 years, height;179±6.13 cm, weight:73.25±6.80 kg ...
Sümeyye Genç, Murat Tutar, Erkan Günay   +2 more
openaire   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Can Complex Training Improve Acute and Long-Lasting Performance in Basketball Players? A Systematic Review

Applied Sciences
Basketball demands a sophisticated blend of tactical, technical, physical, and psychological skills, and various methods have been proposed to prepare players for these demands, including resistance training to enhance strength, power, speed, agility ...
Enrique Flórez Gil, Alejandro Vaquera, Rodrigo Ramírez-Campillo, Javier Sanchez-Sanchez, Alejandro Rodríguez Fernández   +4 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Chronic and post-activation potentiation effects of velocity-based training on neuromuscular performance

, 2023
Velocity-based training is a training method which has been gained popularity over the years. Establishing velocity loss thresholds is a great way of managing the amount of training volume performed by the participant and the amount of fatigue induced ...
Peixoto, José Rafael Gonçalves Sousa
core  

Effect of PAPE induced by different squat loads on jump performance in collegiate female basketball players

BMC Sports Science, Medicine and Rehabilitation
Background Post-activation performance enhancement (PAPE) effectively augments explosive performance, especially in jumping. As female athletes have distinct neuromuscular and biomechanical traits that may affect the PAPE response, the optimal squat load
Xu Si, Yu Hang Liu, Xin Ru Zhou, Shao Jie Ning, Qing Bo Li   +4 more
doaj   +1 more source