Results 111 to 120 of about 95,371 (247)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Post-Activation Performance Enhancement Through Variable Loading Maintains Power Output Over Five Sets in Highly Trained Athletes

, 2023
The goal was to examine the acute effects of five sets of variable loading (VL) on the post-activation performance enhancement (PAPE) response during a live training session in highly trained athletes.
Bommarito, Pete, Rocanelli, Robert, Yunes, Pedro, Mokha, Monique, Siegel, Morgan   +4 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Acute and Chronic Effects of Muscle Strength Training on Physical Fitness in Boxers: A Scoping Review

Applied Sciences
The aim of this scoping review was to compile the current evidence and provide a summary of the acute and chronic effects of muscle strength training on the physical fitness of amateur boxers and provide recommendations to optimize their physical ...
Jordan Hernandez-Martinez, Izham Cid-Calfucura, Pablo Valdés-Badilla, Emerson Franchini, José Manuel García-García, Tomás Herrera-Valenzuela   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Self-enhancement and self-protection: what they are and what they do [PDF]

, 2009
We define self-enhancement and self-protection as interests that individuals have in advancing one or more self-domains or defending against negative self-views. We review ways in which people pursue self-enhancement and self-protection, discuss the role
Sedikides, Constantine, Constantine Sedikides, Alicke, Mark D., Mark D. Alicke   +3 more
core   +1 more source

Acute effects of unilateral conditioning activity on unilateral and bilateral jumping performance and bilateral strength asymmetry

Scientific Reports
The majority of motor tasks in sports are executed unilaterally, however research on the impact of unilateral conditioning activities (CAs) on both unilateral and bilateral sports tasks remains limited.
Jonatan Helbin, Agata Latocha, Michał Spieszny, Paulina Ewertowska, Michał Wilk, Michał Krzysztofik   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Impact of Post-Activation Performance Enhancement Protocols on Vertical Jumps: Systematic Review

Background: The post-activation performance enhancement (PAPE) protocol is frequently utilized to enhance athletic performance through high-intensity stimuli.
Krzysztof Kasicki, Michał Spieszny, Tadeusz Ambroży, Łukasz Rydzik, Piotr Koteja   +4 more
core   +1 more source