Results 121 to 130 of about 95,371 (247)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ACCENTUATED ECCENTRIC OVERLOAD AS A POST-ACTIVATION POTENTIATION ENHANCEMENT OF SHORT SPRINT PERFORMANCE

, 2023
John Kennington, Jarrod Kennington, Cole Anderton, Gene Hurst, Rebecca R. Rogers, Christopher G. Ballmann, FACSM, Tyler D. Williams. Samford, Birmingham, AL. BACKGROUND: Post-activation potentiation enhancement (PAPE) strategies are used to improve acute
Ballmann, FACSM, CG, Rogers, RR, Kennington, J, Anderton, C, Williams, TD, Hurst, G   +5 more
core  

No evidence for PAPE-induced jumping performance enhancement following isometric and treadmill warm-ups in team sport athletes

Baltic Journal of Health and Physical Activity
Background: This study aimed to determine whether an isometric PAPE‐based warm-up could enhance jumping performance compared to a traditional treadmill jogging warm-up in team sport athletes.
Artur TERBALYAN, Adam MASZCZYK, Robert ROCZNIOK   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

How repeatable is PAPE effect: the impact of in-season isometric squat activation on countermovement jump performance enhancement in national level soccer players

BMC Sports Science, Medicine and Rehabilitation
Background The post-activation performance enhancement (PAPE) effect has been widely studied; however, its repeatability across training sessions during the competitive season in team sports has not yet been verified.
Jakub Jarosz, Dawid Gawel, Pawel Grycmann, Piotr Aschenbrenner, Michal Spieszny, Michal Wilk, Michal Krzysztofik   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

The effects of different exercise loads in plyometric resistance training on respiratory and hormonal levels in female volleyball players

Frontiers in Physiology
BackgroundThe present study set out to ascertain the effects of combined exercises, consisting of resistance training and plyometric exercises at varying degrees of intensity, on biochemical and respiratory parameters in female volleyball players ...
Korhan Kavuran, Ercan Tizar, Diclehan Oral, Ramazan Erdoğan, Baha Engin Çelikel, Tülay Ceylan, Süreyya Yonca Sezer, Baykal Karataş   +7 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

THE ACUTE EFFECT OF LOWER BODY ACTIVATION WITH MINI-BANDS ON JUMP HEIGHT IN FEMALE BASKETBALL PLAYERS

Spormetre Beden Eğitimi ve Spor Bilimleri Dergisi
The purpose of this study was to investigate the acute effects of a mini-band PAPE protocol on CMJ height in female basketball players and to determine whether this effect varies across different playing positions.
Çağdaş Özgür Cengizel
doaj   +1 more source