Results 101 to 110 of about 95,371 (247)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Impact of Post Activation Performance Enhancement Protocol on Specific Sport Performance of Vertical Jump: A Systematic Review

The Post Activation Performance Enhancement (PAPE) protocol is frequently utilized to enhance athletic performance through high-intensity stimuli. Despite its popularity, the effectiveness and mechanisms of PAPE remain unclear, particularly in the ...
Krzysztof Kasicki, Michał Spieszny, Tadeusz Ambroży, Łukasz Rydzik, Piotr Koteja   +4 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Effects of Loaded Plyometric Exercise on Post-Activation Performance Enhancement of Countermovement Jump in Sedentary Men

, 2022
Purpose: Explosive performance is increased right after performing loaded resistance exercise, which is known as post-activation performance enhancement (PAPE).
Greco, Camila Coelho [UNESP], Lima, Leonardo Coelho Rabello [UNESP], Mantovani, Guilherme Beneduzzi [UNESP], Denadai, Benedito Sérgio [UNESP], Souza, Victor Alvino [UNESP], Nosaka, Kazunori, Barreto, Renan Vieira [UNESP]   +6 more
core   +1 more source

Whole-Body Vibration (WBV) as a Conditioning Activity for Roundhouse Kick (mawashi geri) Performance in Karate

Journal of Functional Morphology and Kinesiology
Karate athletes strategically use lower-limb techniques in combat, with the roundhouse kick (mawashi geri) being highly effective in kumite. To quickly improve the technical performance before training or competitions, conditioning activities (CAs) are ...
Johan Robalino, Lucieli Teresa Cambri, André Cavalcante, Emerson Franchini, Bruno Mezêncio, Jacielle Carolina Ferreira   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Replication Data for: Mediating effects of caffeine ingestion and post-activation performance enhancement on reactive dive times in goalkeepers

This is the data repository for the project entitled: Mediating effects of caffeine ingestion and post-activation performance enhancement on reactive dive times in ...
Bahdur, Khatija, Kramer, Mark, Impey, Justin   +2 more
core   +1 more source

Effects of Warm-Ups with Weighted Vests and Resistance Bands on Physical Fitness and Combat Ability of Kumite Karate Athletes

Sports
The purpose of this study was to investigate whether a dynamic warm-up either with weighted vests (WVs) or with resistance bands (RBs) may enhance the physical fitness and combat ability of kumite karate athletes. Nine male athletes (age range from 16 to
Christos Ioannides, Chrysanthi Despotopoulou, Marios Hadjicharalambous, Nikolaos Zaras   +3 more
doaj   +1 more source