Results 101 to 110 of about 14,728,127 (259)

Effects of Warm-Ups with Weighted Vests and Resistance Bands on Physical Fitness and Combat Ability of Kumite Karate Athletes

Sports
The purpose of this study was to investigate whether a dynamic warm-up either with weighted vests (WVs) or with resistance bands (RBs) may enhance the physical fitness and combat ability of kumite karate athletes. Nine male athletes (age range from 16 to
Christos Ioannides, Chrysanthi Despotopoulou, Marios Hadjicharalambous, Nikolaos Zaras   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

K-12 education : reviewing the research on charter school performance

, 2007
"A report to the Legislative Post Audit Committee"--Cover.; "May 2007."; Includes bibliographical references (p. 15-16)

core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Replication Data for: Mediating effects of caffeine ingestion and post-activation performance enhancement on reactive dive times in goalkeepers

This is the data repository for the project entitled: Mediating effects of caffeine ingestion and post-activation performance enhancement on reactive dive times in ...
Bahdur, Khatija, Kramer, Mark, Impey, Justin   +2 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Acute and Chronic Effects of Muscle Strength Training on Physical Fitness in Boxers: A Scoping Review

Applied Sciences
The aim of this scoping review was to compile the current evidence and provide a summary of the acute and chronic effects of muscle strength training on the physical fitness of amateur boxers and provide recommendations to optimize their physical ...
Jordan Hernandez-Martinez, Izham Cid-Calfucura, Pablo Valdés-Badilla, Emerson Franchini, José Manuel García-García, Tomás Herrera-Valenzuela   +5 more
doaj   +1 more source

How post-activation performance enhancements affect semi-tethered swimming kinetics

, 2020
Introduction: When an action induces acute fatigue, it may be followed by a period of potentiated force production capability, termed as Post-activation Potentiation (PAP). One of the training philosophy principles PAP is based on is complex training, which consists on providing a resistive conditioning exercise as similar as possible to the real ...
Cuenca Fernández, Francisco, Ruiz Navarro, Jesús Juan, Arellano Colomina, Raúl   +2 more
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Acute effects of unilateral conditioning activity on unilateral and bilateral jumping performance and bilateral strength asymmetry

Scientific Reports
The majority of motor tasks in sports are executed unilaterally, however research on the impact of unilateral conditioning activities (CAs) on both unilateral and bilateral sports tasks remains limited.
Jonatan Helbin, Agata Latocha, Michał Spieszny, Paulina Ewertowska, Michał Wilk, Michał Krzysztofik   +5 more
doaj   +1 more source