Results 71 to 80 of about 14,728,127 (259)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Beyond the warm-up: Understanding the post-activation performance enhancement

Turkish Journal of Sports Medicine
This review explores the concept of Post-Activation Performance Enhancement (PAPE), a critical phenomenon in sports science that focuses on the acute improvement of muscular performance following high-intensity conditioning activities. PAPE has emerged as distinct from post-activation potentiation, with an emphasis on enhancing voluntary muscle ...
Taylan Aytaç, Ayşe Kin İşler
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effects of 6 weeks of complex training on athletic performance and post-activation performance enhancement effect magnitude in soccer players: a cross-sectional randomized study

This study aimed to determine the effect of complex training (CT) on post-activation performance enhancement (PAPE) effect magnitude, 5- and 30-m linear sprint, 5-0-5 change of-direction (COD), back squat (BS) and hip thrust (HT) one-repetition maximum ...
Jakub Jarosz, Michał Krzysztofik, Petr Stastny, Robert Urbański, Piotr Aschenbrenner   +4 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Acute effects of eccentric overload training with different loading doses in male sprinters

Heliyon
Objective: The primary objective of this study was to investigate the immediate effects of two doses (Dose1 and Dose2,D1 and D2) of inertial Flywheel Eccentric Overload (FEOL), Eccentric Hook (EH), and High-intensity Half Squat (HHS) on muscle ...
Yuhang Liu, Junjie Zhang, Zhongzhong Hu, Zixuan Zhong, Xiaoyi Yuan   +4 more
doaj   +1 more source

Heavier loads in flywheel exercise induce greater post-activation performance enhancement in countermovement jumps compared to heavy Smith machine squats in males

We evaluated the effects of post-activation performance enhancement through flywheel exercise with varying inertial loads compared to traditional resistance exercise on countermovement jump performance and muscle recruitment.
Wei Zhang, Haoyang Liu, Mengjie Yu, Olivier Girard, Bing Yan, Zhe Wang, Yang Wang, Jianhua Shi   +7 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Effects of different activation strategies on standing start performance in elite female track cyclists

Scientific Reports
PAPE (post-activation performance enhancement) has gained attention in sports science due to its potential to enhance athletic performance. This study aimed to investigate the effects of different PAPE activation methods, including non-activation (CON ...
Yapu Liang, Tianhe Li, Jiayue Liu, Yahui Gao, Shanju Bao, Yufang Guo, Qi Liu, Xu Huang, Qi Zhong, Lehai Lin   +9 more
doaj   +1 more source