Results 111 to 120 of about 67,475 (271)

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

ANALYZING THE EFFECT OF POST ACTIVATION POTENTIATION ON VERTICAL JUMP HEIGHT IN VOLLEYBALL PLAYERS

, 2019
The aim of the study was to find the effect of post activation potentiation (PAP) on jump performance in volleyball players and to compare its effects between males and females. Forty volleyball players were randomly divided into control and experimental
Shenoy, Shweta, Sarika, S., Kaur, Manpreet Bir   +2 more
core   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Post-activation potentiation: Honors thesis

, 2018
Heavy resistance exercise may induce post-activation potentiation (PAP), enhancing performance of a subsequent biomechanically similar movement. Performance is enhanced when potentiation is greater than fatigue.
D'Abrosca, Brya
core  

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

The effect of post-activation potentiation on velocity of throws in Lithuanian cadet judo championship medalists.

, 2017
Research object – The effect of post-activation potentiation on velocity of throws. Research subjects – 9 physically active Lithuanian male judo athletes that were medalists in Lithuanian championship in cadets age group (n=9).
Malinovskij, Robertas,
core  

The effects of multiple factors on post-activation potentiation and performance enhancement: a narrative review

Purpose: The aim of this review was to examine the effects of various factors, including recovery time, conditioning activity, range of motion, gender, age, fiber type percentage, training experience, and supplement intake, on post-activation ...
Domenico Savio Salvatore Vicari, Alessandro Tamassia, Eugenio Formiglio, Marco Gervasi, Antonino Patti, Valerio Giustino, Eneko Fernández-Peña   +6 more
core   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Post activation potentiation can be induced without impairing tendon stiffness

, 2014
PURPOSE: This study aimed to investigate conditioning effects from a single 6-s plantar flexion maximal voluntary isometric contraction (MVIC) on Achilles tendon stiffness (ATS) and twitch properties of the triceps surae in athletes.METHODS: Peak twitch (
Ekblom, Maria M,, Tarassova, Olga,, Arndt, Anton,, Gago, Paulo,   +3 more
core   +1 more source