Results 31 to 40 of about 1,751 (120)

A Pharmacogenetic Survey of Androgen Receptor (CAG)N and (GGN)N Polymorphisms in Patients Experiencing Long Term Side Effects after Finasteride Discontinuation

The International Journal of Biological Markers, 2014
Finasteride is a steroid 5-alpha-reductase inhibitor, approved for the treatment of androgenetic alopecia (AGA) and benign prostate hyperplasia. In some patients the treatment is associated with adverse side effects that could become persistent after ...
Erika Cecchin PhD, Elena De Mattia, Giorgio Mazzon, Sabina Cauci, Carlo Trombetta, Giuseppe Toffoli   +5 more
doaj   +1 more source

Androgenic alopecia; the risk–benefit ratio of Finasteride

Journal of Mind and Medical Sciences, 2018
Finasteride is currently approved and largely used as a therapeutic option for androgenetic alopecia. Apparently a safe drug and effective at the onset, several concerns appeared over time regarding the frequency and magnitude of finasteride adverse ...
David L. Rowland, Ion G. Motofei, Ioana Păunică, Petrișor Banu, Mihaela F. Nistor, Stana Păunică, Vlad D. Constantin   +6 more
doaj   +1 more source

Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia

Sexual Medicine, 2017
Introduction: Long-term adverse symptoms of men who used oral finasteride against androgenic alopecia have been recently described as post-finasteride syndrome (PFS).
Sabina Cauci, PhD, Giovanni Chiriacò, MD, Erika Cecchin, MS, Giuseppe Toffoli, MD, Serena Xodo, MD, Giuseppe Stinco, MD, Carlo Trombetta, MD   +6 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study

Endocrine Connections, 2019
Context: Post-finasteride syndrome (PFS) occurs in patients with androgenic alopecia after suspension of the finasteride treatment, leading to a large variety of persistent side effects.
Roberto Cosimo Melcangi, Livio Casarini, Marco Marino, Daniele Santi, Samantha Sperduti, Silvia Giatti, Silvia Diviccaro, Maria Grimoldi, Donatella Caruso, Guido Cavaletti, Manuela Simoni   +10 more
doaj   +1 more source

Systemic Absorption and Pharmacokinetics of Five Novel Topical Dermatologic Agents: A Review

JEADV Clinical Practice, EarlyView.
ABSTRACT In recent years, innovative topical medications with novel mechanisms of action have emerged to treat common dermatologic conditions such as acne, atopic dermatitis, vitiligo, and actinic keratoses. These molecularly targeted therapies offer improved safety and tolerability compared to traditional options like corticosteroids.
Mary Dyson, Kara Hurley, Hannah Chaudhury, Lara Shehadeh, Cameron West   +4 more
wiley   +1 more source

The Role of DNA Methyltransferases in Urinary System Diseases

Cancer Innovation, Volume 4, Issue 6, December 2025.
Multiple signaling pathways mediated by DNMTs in the formation of renal fibrosis: (a) DNMTs suppress the expression of transcription factor KLF4 by mediating promoter hypermethylation, thereby promoting epithelial–mesenchymal transition and contributing to the development of renal fibrosis; (b) oxidative stress can upregulate the levels of DNMTs, which
Wei Dong, Shengbin Pei, Dacheng Zhu, Cheng Zeng, Yue Qiu, Yuxin Wu, Xinlu Jia, Siqi Zhang, Chao Li, Wenjuan Zhang, Wenbing Zhang, Zhihua Chen   +11 more
wiley   +1 more source

Effects of Angelica archangelica Extract on Overactive Bladder: A Pilot Randomized Controlled Trial

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Overactive bladder (OAB) affects 10.8% of men and 12.8% of women in Europe, significantly impairing quality of life (QoL). This randomized, triple‐blind, controlled pilot trial evaluated Angelica archangelica (AA) leaf extract versus placebo in 143 adults with OAB over 6 weeks. Outcomes were measured using a voiding diary and IPSS.
Jaime López‐Seoane, Eva Gesteiro, María José Castro‐Alija, Carlos Quesada‐González, Margarita Pérez‐Ruiz, Marcela González‐Gross   +5 more
wiley   +1 more source

Oral finasteride use and sexual adverse events: signal detection from disproportionality analyses of data from the United States Food and Drug Administration Adverse Event Reporting System

Journal of Dermatological Treatment
Background Oral finasteride 1 milligram (1 mg) daily—which is a 5-alpha reductase inhibitor (5-ARI) approved by the Food and Drug Administration (FDA) for androgenetic alopecia—is linked to sexual adverse events (AEs). However, it remains unclear whether
Aditya K. Gupta, Mesbah Talukder, Greg Williams, Mary A. Bamimore   +3 more
doaj   +1 more source

Epidemiology and organized testing for the diagnosis of prostate cancer in Sweden

UroPrecision, Volume 3, Issue 4, Page 210-225, December 2025.
Abstract Prostate cancer is the most diagnosed cancer and the leading cause of cancer‐related death among men in Sweden. The natural history and risk factors of prostate cancer, particularly within hereditary populations, have been extensively studied in the Swedish context. Despite the absence of national recommendations for prostate‐specific antigen (
Eugen Y. H. Wang
wiley   +1 more source