Results 91 to 100 of about 6,379,811 (286)
METTL1-mediated m7G modification regulates hair follicle cycle via the HOXC13/FOXN1/DSG4 axis.
PLoS GeneticsRapid hair follicle cycling requires precise fate commitment and differentiation of hair follicle stem cells. While the essential role of transcription factors in establishing cell identity is well recognized, how cells control its protein synthesis to ...
Xinyan Gan +10 more
doaj +1 more source
Identified sites of potential URI post-transcriptional modification.
, 2013 Potential URI post-transcriptional modifications detected by our mass spectrometry analysis. Phosphorylation and acetylation sites are reported.
Susan Ha (411322) +5 more
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease [PDF]
The human mitochondrial genome (mtDNA) encodes 22 tRNAs (mt-tRNAs) that are necessary for the intraorganellar translation of the 13 mtDNA-encoded subunits of the mitochondrial respiratory chain complexes.
Powell CA, Nicholls TJ, Minczuk M
core +3 more sources
RNA Methylation in ncRNA: Classes, Detection, and Molecular Associations
Frontiers in Genetics, 2018 Nearly all classes of coding and non-coding RNA undergo post-transcriptional modification, as more than 150 distinct modification types have been reported.
Giulia Romano +3 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng
Cell Communication and SignalingBackground Androgens are essential hormones for testicular development and the maintenance of male fertility. Environmental factors, stress, aging, and psychological conditions can disrupt androgen production, impacting the androgen signaling pathway and
Wenhui Zhai +8 more
doaj +1 more source
Mapping post-transcriptional modifications in Staphylococcus aureus tRNAs by nanoLC/MSMS
Biochimie, 2019 RNA modifications are involved in numerous biological processes. These modifications are constitutive or modulated in response to adaptive processes and can impact RNA base-pairing formation, protein recognition, RNA structure and stability. tRNAs are the most abundantly modified RNA molecules.
Antoine, Laura +4 more
openaire +3 more sources
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Advanced SciencePolyploidization is a major driving force for evolutionary innovation and environmental adaptation in plants and is notably prevalent in kiwifruits.
Xiaoli Hu +14 more
doaj +1 more source