Results 31 to 40 of about 571,207 (361)
Regulation of PD-L1 expression in the tumor microenvironment
Journal of Hematology & Oncology, 2021 Programmed death-ligand 1 (PD-L1) on cancer cells engages with programmed cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple cancer types, the PD-1/PD-L1 axis is the major speed-limiting step of the anti-cancer immune
Ming Yi +4 more
doaj +1 more source
Quantifying Dynamic Regulation in Metabolic Pathways with Nonparametric Flux Inference [PDF]
, 2019 One of the central tasks in systems biology is to understand how cells regulate their metabolism. Hierarchical regulation analysis is a powerful tool to study this regulation at the metabolic, gene-expression, and signaling levels.
He, Fei, Stumpf, Michael P H
core +1 more source
5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme [PDF]
, 2015 5-hydroxymethylcytosine is a new epigenetic modification deriving from the oxidation of 5-methylcytosine by the TET hydroxylase enzymes. DNA hydroxymethylation drives DNA demethylation events and is involved in the control of gene expression ...
CAIAFA, Paola +3 more
core +9 more sources
Editorial: Post-transcriptional modifications in cancer immunity and immunotherapy [PDF]
Frontiers in ImmunologyGaigai Wei +3 more
openalex +3 more sources
An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]
, 2015 Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro +1 more
core +1 more source
KAP1 is a Novel Substrate for the Arginine Methyltransferase PRMT5 [PDF]
, 2015 KRAB-associated protein 1 (KAP1), the transcriptional corepressor of Kruppel-associated box zinc finger proteins (KRAB-ZFPs), is subjected to multiple post-translational modifications that are involved in fine-tuning of the multiple biological functions ...
Cesaro, Elena +4 more
core +2 more sources
Distribution and frequencies of post-transcriptional modifications in tRNAs [PDF]
RNA Biology, 2014 Functional tRNA molecules always contain a wide variety of post-transcriptionally modified nucleosides. These modifications stabilize tRNA structure, allow for proper interaction with other macromolecules and fine-tune the decoding of mRNAs during translation. Their presence in functionally important regions of tRNA is conserved in all domains of life.
Magdalena A, Machnicka +3 more
openaire +2 more sources
Phospho.ELM: A database of experimentally verified phosphorylation sites in eukaryotic proteins
BMC Bioinformatics, 2004 Background Post-translational phosphorylation is one of the most common protein modifications. Phosphoserine, threonine and tyrosine residues play critical roles in the regulation of many cellular processes. The fast growing number of research reports on
Via Allegra +8 more
doaj +1 more source
Epigenetic aberrations and cancer [PDF]
, 2006 The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core +3 more sources
Molecular Microbiology, 2019 Members of actinobacterial genus Streptomyces possess a sophisticated life cycle and are the deepest source of bioactive secondary metabolites. Although morphogenesis and secondary metabolism are subject to transcriptional co‐regulation, streptomycetes ...
O. Koshla +10 more
semanticscholar +1 more source