Post-transcriptional modification

Results 31 to 40 of about 207,666 (97)

Guide snoRNAs: Drivers or Passengers in Human Disease?

Biology, 2018
In every domain of life, RNA-protein interactions play a significant role in co- and post-transcriptional modifications and mRNA translation. RNA performs diverse roles inside the cell, and therefore any aberrancy in their function can cause various ...
Manisha Deogharia, Mrinmoyee Majumder
doaj +1 more source

The m6A reader PRRC2A is essential for meiosis I completion during spermatogenesis

Nature Communications, 2023
Modification of RNA with m6A has been shown to be important during spermatogenesis. Here they identify post-transcriptional functions of PRRC2A, showing it promotes transcriptome transition from spermatogonia to spermatocytes and the translation of genes
Xinshui Tan +4 more
doaj +1 more source

Human lineage mutations regulate RNA-protein binding of conserved genes NTRK2 and ITPR1 involved in human evolution

General Psychiatry
Background The role of human lineage mutations (HLMs) in human evolution through post-transcriptional modification is unclear.Aims To investigate the contribution of HLMs to human evolution through post-transcriptional modification.Methods We applied a ...
Min Zhao +4 more
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Modulation of the Proteostasis Machinery to Overcome Stress Caused by Diminished Levels of t6A‐Modified tRNAs in Drosophila

Biomolecules, 2017
Transfer RNAs (tRNAs) harbor a subset of post‐transcriptional modifications required for structural stability or decoding function. N6‐threonylcarbamoyladenosine (t6A) is a universally conserved modification found at position 37 in tRNA that pair A ...
Diego Rojas‐Benítez, Cristián Eggers, Alvaro Glavic +2 more
doaj +1 more source

RNA Methylation in ncRNA: Classes, Detection, and Molecular Associations

Frontiers in Genetics, 2018
Nearly all classes of coding and non-coding RNA undergo post-transcriptional modification, as more than 150 distinct modification types have been reported.
Giulia Romano +3 more
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Transcriptional and Post-transcriptional Regulation of Lignin Biosynthesis Pathway Genes in Populus

Frontiers in Plant Science, 2020
Lignin is a heterogeneous polymer of aromatic subunits derived from phenylalanine. It is polymerized in intimate proximity to the polysaccharide components in plant cell walls and provides additional rigidity and compressive strength for plants ...
Jin Zhang +9 more
doaj +1 more source

Interaction of MaERF11 with the E3 ubiquitin ligase MaRFA1 is involved in the regulation of banana starch degradation during postharvest ripening

Horticultural Plant Journal
Banana fruit ripening is a highly regulatory process involving various layers consisting of transcriptional regulation, epigenetic factor, and post-translational modification.
Mengge Jiang +8 more
doaj +1 more source

Subgenome Dominance in Allotetraploid Actinidia valvata Regulates RNA m6A Modification for Waterlogging Tolerance

Advanced Science
Polyploidization is a major driving force for evolutionary innovation and environmental adaptation in plants and is notably prevalent in kiwifruits.
Xiaoli Hu +14 more
doaj +1 more source

Androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng

Cell Communication and Signaling
Background Androgens are essential hormones for testicular development and the maintenance of male fertility. Environmental factors, stress, aging, and psychological conditions can disrupt androgen production, impacting the androgen signaling pathway and
Wenhui Zhai +8 more
doaj +1 more source

Post-Transcriptional Modification by Alternative Splicing and Pathogenic Splicing Variants in Cardiovascular Development and Congenital Heart Defects. [PDF]

Int J Mol Sci, 2023
Mehta Z, Touma M.
europepmc +1 more source

cancer
science
post-translational modification

transcriptional regulation
rna modification
tumor microenvironment

immunotherapy