Results 41 to 50 of about 6,012,126 (285)

Complex transcriptional and post‐transcriptional regulation of an enzyme for lipopolysaccharide modification [PDF]

Molecular Microbiology, 2013
SummaryThe PhoQ/PhoP two‐component system activates many genes for lipopolysaccharide (LPS) modification when cells are grown at low Mg2+ concentrations. An additional target of PhoQ and PhoP is MgrR, an Hfq‐dependent small RNA that negatively regulates expression of eptB, also encoding a protein that carries out LPS modification.
Kyung, Moon, David A, Six, Hyun-Jung, Lee, Christian R H, Raetz, Susan, Gottesman   +4 more
openaire   +2 more sources

Multi-faceted regulation of CREB family transcription factors

Frontiers in Molecular Neuroscience
cAMP response element-binding protein (CREB) is a ubiquitously expressed nuclear transcription factor, which can be constitutively activated regardless of external stimuli or be inducibly activated by external factors such as stressors, hormones ...
Md Arifur Rahman Chowdhury, Md Arifur Rahman Chowdhury, Md Mazedul Haq, Md Mazedul Haq, Jeong Hwan Lee, Sangyun Jeong, Sangyun Jeong   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

Nature Communications, 2017
Yap is a transcriptional factor involved in tumorigenesis. Here the authors show that a previously unknown post-translational modification of Yap, O-GlcNAcylation, increases its transcriptional activity and is required for high glucose-induced liver ...
Xiao Zhang, Yongxia Qiao, Qi Wu, Yan Chen, Shaowu Zou, Xiangfan Liu, Guoqing Zhu, Yinghui Zhao, Yuxin Chen, Yongchun Yu, Qiuhui Pan, Jiayi Wang, Fenyong Sun   +12 more
doaj   +1 more source

Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice

Nature Communications, 2021
Post-transcriptional modification of RNA can contribute to regulating behavior. Here, the authors show that modulating the expression of Fto results in epitranscriptomic changes in the mouse hippocampus associated with depression-like behavior.
Shu Liu, Jianbo Xiu, Caiyun Zhu, Kexin Meng, Chen Li, Rongrong Han, Tingfu Du, Lanlan Li, Lingdan Xu, Renjie Liu, Wanwan Zhu, Yan Shen, Qi Xu   +12 more
doaj   +1 more source

Decoding co-/post-transcriptional complexities of plant transcriptomes and epitranscriptome using next-generation sequencing technologies [PDF]

, 2020
Next-generation sequencing (NGS) technologies – Illumina RNA-seq, Pacific Biosciences isoform sequencing (PacBio Iso-seq), and Oxford Nanopore direct RNA sequencing (DRS) - have revealed the complexity of plant transcriptomes and their regulation at the ...
Reddy, A. S. N., Gu, L., Ben-Hur, A., Syed, N., Dong, S., Huang, J.   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Comprehensive Structural and Substrate Specificity Classification of the Saccharomyces cerevisiae Methyltransferome [PDF]

, 2011
Methylation is one of the most common chemical modifications of biologically active molecules and it occurs in all life forms. Its functional role is very diverse and involves many essential cellular processes, such as signal transduction ...
Kudlicki, Andrzej, Wlodarski Tomasz, Maga Rowicka, Rowicka Maga, Kudlicki Andrzej, Ginalski, Krzysztof, Rychlewski Leszek, Dziembowski, Andrzej, Rychlewski, Leszek, Ginalski Krzysztof, Joanna Towpik, Dziembowski Andrzej, Andrzej Kudlicki, Kutner, Jan, Andrzej Dziembowski, Knizewski Lukasz, Lukasz Knizewski, Leszek Rychlewski, Wlodarski, Tomasz, Jan Kutner, Knizewski, Lukasz, Towpik, Joanna, Towpik Joanna, Rowicka, Magda, Kutner Jan, Krzysztof Ginalski, Tomasz Wlodarski   +26 more
core   +3 more sources