Results 41 to 50 of about 6,379,811 (286)

Modeling cross‐talk of RNA modification enzymes reveals tumor microenvironment‐associated clinical significance and immunotherapy prediction in hepatobiliary malignancy

open access: yesMedComm, 2023
RNA modification includes four main types, N6‐methyladenosine, N1‐methyladenosine, alternative polyadenylation (APA), and adenosine‐to‐inosine (A‐to‐I) RNA editing, involving 41 enzymes that serve as “writers”, “readers” and “erasers”.
Feng Qi   +6 more
doaj   +1 more source

Post-transcriptional modifications are very important after all [PDF]

open access: yesRNA Biology, 2014
In the beginning there was RNA and our lives as molecular biologists and biochemists proceeded simply.
openaire   +2 more sources

Complex transcriptional and post‐transcriptional regulation of an enzyme for lipopolysaccharide modification [PDF]

open access: yesMolecular Microbiology, 2013
SummaryThe PhoQ/PhoP two‐component system activates many genes for lipopolysaccharide (LPS) modification when cells are grown at low Mg2+ concentrations. An additional target of PhoQ and PhoP is MgrR, an Hfq‐dependent small RNA that negatively regulates expression of eptB, also encoding a protein that carries out LPS modification.
Kyung, Moon   +4 more
openaire   +2 more sources

Transcriptional gene silencing mutants in "Arabidopsis thaliana" and their impact on nuclear architecture and heterochromatin organization [PDF]

open access: yes, 2004
The epigenetic regulation of gene expression is defined by covalent modifications of DNA and histone tails as well as by chromatin structure and nuclear architecture.
Valeska Probst, Aline
core   +1 more source

Multi-faceted regulation of CREB family transcription factors

open access: yesFrontiers in Molecular Neuroscience
cAMP response element-binding protein (CREB) is a ubiquitously expressed nuclear transcription factor, which can be constitutively activated regardless of external stimuli or be inducibly activated by external factors such as stressors, hormones ...
Md Arifur Rahman Chowdhury   +6 more
doaj   +1 more source

Combining tRNA sequencing methods to characterize plant tRNA expression and post-transcriptional modification

open access: yes, 2020
Differences in tRNA expression have been implicated in a remarkable number of biological processes. There is growing evidence that tRNA genes can play dramatically different roles depending on both expression and post-transcriptional modification, yet ...
Thalia Salinas-Giegé (8372601)   +7 more
core   +1 more source

Feeding, Fear, and Acceptance: Caregivers’ Experiences of Nutritional Support During Childhood Cancer Treatment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques   +5 more
wiley   +1 more source

Transcriptional control: repression by local chromatin modification

open access: yes, 2008
It is becoming increasingly clear that chromatin modification plays a fundamental part in transcriptional control. Recent studies provide new insights into how transcriptional repressors, in addition to blocking activators, may recruit repression ...
Ip, Y. Tony, Ashraf, Shovon Imtiaz
core   +2 more sources

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng   +3 more
wiley   +1 more source

The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

open access: yesNature Communications, 2017
Yap is a transcriptional factor involved in tumorigenesis. Here the authors show that a previously unknown post-translational modification of Yap, O-GlcNAcylation, increases its transcriptional activity and is required for high glucose-induced liver ...
Xiao Zhang   +12 more
doaj   +1 more source

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