Results 61 to 70 of about 6,379,811 (286)

Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis

Cell Reports, 2019
Summary: The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in histone H3 lysine 27 trimethylation.
Yi Zeng, Rongfang Qiu, Yang Yang, Tianyang Gao, Yu Zheng, Wei Huang, Jie Gao, Kai Zhang, Ruiqiong Liu, Shuang Wang, Yongqiang Hou, Wenqian Yu, Shuai Leng, Dandan Feng, Wei Liu, Xi Zhang, Yan Wang   +16 more
doaj   +1 more source

Decoding co-/post-transcriptional complexities of plant transcriptomes and epitranscriptome using next-generation sequencing technologies [PDF]

, 2020
Next-generation sequencing (NGS) technologies – Illumina RNA-seq, Pacific Biosciences isoform sequencing (PacBio Iso-seq), and Oxford Nanopore direct RNA sequencing (DRS) - have revealed the complexity of plant transcriptomes and their regulation at the ...
Reddy, A. S. N., Gu, L., Ben-Hur, A., Syed, N., Dong, S., Huang, J.   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Two-subunit enzymes involved in eukaryotic post-transcriptional tRNA modification [PDF]

RNA Biology, 2014
tRNA modifications are crucial for efficient and accurate protein translation, with defects often linked to disease. There are 7 cytoplasmic tRNA modifications in the yeast Saccharomyces cerevisiae that are formed by an enzyme consisting of a catalytic subunit and an auxiliary protein, 5 of which require only a single subunit in bacteria, and 2 of ...
Guy, Michael P, Phizicky, Eric M
openaire   +2 more sources

Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications

Cancers, 2023
Ewing sarcoma is the second most common bone tumor in childhood and adolescence. Currently, first-line therapy includes multidrug chemotherapy with surgery and/or radiation. Although most patients initially respond to chemotherapy, recurrent tumors become treatment refractory.
Le Yu, Ian J. Davis, Pengda Liu
openaire   +2 more sources

Regulated post-transcriptional RNA cleavage diversifies the eukaryotic transcriptome. [PDF]

, 2010
The complexity of the eukaryotic transcriptome is generated by the interplay of transcription initiation, termination, alternative splicing, and other forms of post-transcriptional modification. It was recently shown that RNA transcripts may also undergo
Bracken, CP, Cameron P. Bracken, Marjan E. Askarian-Amiri, Gregory J. Goodall, Kolle, Gabriel, Korbie, D., Gardiner, B., Gardiner, Brooke B., Grimmond, SM, Marcel E. Dinger, Tim R. Mercer, Mattick, J., Goodall, GJ, Askarian-Amiri, M., Sean M. Grimmond, John S. Mattick, Mercer, TR, Jan M. Szubert, Szubert, J., Dinger, Marcel E., Bracken, C., Brooke B. Gardiner, Korbie, DJ, Kolle, G., Mattick, JS, Szubert, Jan M., Kolle, G, Goodall, Gregory J., Bracken, Cameron P., Askarian-Amiri, Marjan E., Gabriel Kolle, Darren J. Korbie, Goodall, G., Gardiner, BB, Dinger, M., Grimmond, S., Grimmond, Sean M., Mattick, John S., Korbie, Darren J., Dinger, ME, Mercer, Tim R., Szubert, JM, Mercer, T., Askarian-Amiri, ME   +43 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification

, 2023
Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-angiotensin system, provides protection against several chronic diseases. Besides chronic diseases, ACE2 is the host receptor for SARS-CoV or SARS-CoV-2 virus, mediating the first ...
Tse-Hua Tan, Chia-Wen Wang, Huai-Chia Chuang   +2 more
core   +2 more sources

Deciphering RNA modification and post-transcriptional regulation with NetRNApan

Briefings in Bioinformatics
Abstract RNA modification, which is evolutionarily conserved, is crucial for modulating various biological functions and disease pathogenesis. High resolution transcriptome-wide mapping of RNA modifications has facilitated both data resources and computational prediction of RNA modification.
Haodong Xu, Wankun Deng, Ruifeng Hu 0002, Binfeng Liu, Wenchao Zhang, Lujuan Wang, Lin Qi, Xiaolei Ren 0007, Chao Tu, Zhihong Li, Zhongming Zhao   +10 more
openaire   +3 more sources

Post-transcriptional modification of spliceosomal RNAs is normal in SMN-deficient cells [PDF]

RNA, 2011
The survival of motor neuron (SMN) protein plays an important role in the biogenesis of spliceosomal snRNPs and is one factor required for the integrity of nuclear Cajal bodies (CBs). CBs are enriched in small CB-specific (sca) RNAs, which guide the formation of pseudouridylated and 2′-O-methylated residues in the snRNAs.
Deryusheva, S., Choleza, M., Barbarossa, A., Gall, J. G., Bordonne, R.   +4 more
openaire   +3 more sources