Results 31 to 40 of about 6,379,811 (286)
Cell culture NAIL-MS allows insight into human tRNA and rRNA modification dynamics in vivo
Nature Communications, 2021 Post transcriptional modification of RNAs represents an important layer of gene regulation. Here the authors describe NAIL-MS—a method for monoisotopic RNA labeling in cell culture—demonstrating its capabilities by analyzing the modification kinetics of ...
Matthias Heiss +4 more
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Transcriptome-wide analysis of pseudouridylation in Drosophila melanogaster
G3: Genes, Genomes, Genetics, 2022 Pseudouridine (Psi) is one of the most frequent post-transcriptional modification of RNA. Enzymatic Psi modification occurs on rRNA, snRNA, snoRNA, tRNA, and non-coding RNA and has recently been discovered on mRNA.
Wan Song +3 more
doaj +1 more source
A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs [PDF]
Nucleic Acids Research, 2014 In mammalian mitochondria, 22 species of tRNAs encoded in mitochondrial DNA play crucial roles in the translation of 13 essential subunits of the respiratory chain complexes involved in oxidative phosphorylation. Following transcription, mitochondrial tRNAs are modified by nuclear-encoded tRNA-modifying enzymes. These modifications are required for the
Suzuki, Takeo, Suzuki, Tsutomu
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A role for SUMO modification in transcriptional repression and activation [PDF]
, 2007 Since the discovery of the SUMO (small ubiquitin-related modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
Lyst, M J, Stancheva, I
core +1 more source
Biomarker Research, 2023 N6-methyladenosine (m6A) is considered as the most common and important internal transcript modification in several diseases like type 2 diabetes, schizophrenia and especially cancer.
Jinxin Tang +7 more
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Post-transcriptional modifications to tRNA—a response to the genetic code degeneracy [PDF]
RNA, 2015 We used to think of the genetic code degeneracy as an obligatory process resulting from assigning 61 sense codons to the 20 amino acids in protein. In this degeneracy, 18 of the 20 amino acids are endowed with multiple codons, and the conventional wisdom was that each of the 18 was translated equally from each codon.
Hou, Ya-Ming, Gamper, Howard, Yang, Wei
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Post-transcriptional regulation in the developing embryo [PDF]
, 2019 Embryonic development is critically reliant on well-defined spatial and temporal patterns of gene expression. These patterns are often achieved through the regulation of gene expression at the mRNA level.
Fernandes, Sara Maria Ferreira
core +1 more source
Post-transcriptional nucleotide modification and alternative folding of RNA [PDF]
Nucleic Acids Research, 2006 Alternative foldings are an inherent property of RNA and a ubiquitous problem in scientific investigations. To a living organism, alternative foldings can be a blessing or a problem, and so nature has found both, ways to harness this property and ways to avoid the drawbacks.
openaire +3 more sources
Post-transcriptional features quantified in modeled genes.
, 2016 Post-transcriptional features quantified in modeled genes.
Angela Re (3385214) +2 more
core +1 more source
Multilevel Regulation of Abiotic Stress Responses in Plants
Frontiers in Plant Science, 2017 The sessile lifestyle of plants requires them to cope with stresses in situ. Plants overcome abiotic stresses by altering structure/morphology, and in some extreme conditions, by compressing the life cycle to survive the stresses in the form of seeds ...
David C. Haak +6 more
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