Results 11 to 20 of about 6,379,811 (286)
Transcriptional corepressor activity of CtBP1 is regulated by ISG15 modification
Animal Cells and SystemsC-terminal binding protein 1 (CtBP1) is a critical transcriptional corepressor of many tumor suppressor genes and plays diverse roles in the progression of cancers.
Yun Hwan Lim +3 more
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The role of post-transcriptional modifications during development
Biologia Futura, 2022 AbstractWhile the existence of post-transcriptional modifications of RNA nucleotides has been known for decades, in most RNA species the exact positions of these modifications and their physiological function have been elusive until recently. Technological advances, such as high-throughput next-generation sequencing (NGS) methods and nanopore-based ...
Renáta Hamar, Máté Varga
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An extended dsRBD is required for post-transcriptional modification in human tRNAs. [PDF]
Nucleic Acids Res, 2015 In tRNA, dihydrouridine is a conserved modified base generated by the post-transcriptional reduction of uridine. Formation of dihydrouridine 20, located in the D-loop, is catalyzed by dihydrouridine synthase 2 (Dus2). Human Dus2 (HsDus2) expression is upregulated in lung cancers, offering a growth advantage throughout its ability to interact with ...
Bou-Nader C +8 more
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Post-transcriptional modifications in development and stem cells [PDF]
Development, 2016 Cells adapt to their environment by linking external stimuli to an intricate network of transcriptional, post-transcriptional and translational processes. Among these, mechanisms that couple environmental cues to the regulation of protein translation are not well understood.
Michaela Frye, Sandra Blanco
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Post-transcriptional gene regulation by mRNA modifications [PDF]
Nature Reviews Molecular Cell Biology, 2016 The recent discovery of reversible mRNA methylation has opened a new realm of post-transcriptional gene regulation in eukaryotes. The identification and functional characterization of proteins that specifically recognize RNA N6-methyladenosine (m6A) unveiled it as a modification that cells utilize to accelerate mRNA metabolism and translation.
Boxuan Simen, Zhao +2 more
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Post-Transcriptional Modifications of RNA as Regulators of Apoptosis in Glioblastoma
International Journal of Molecular Sciences, 2022 This review is devoted to changes in the post-transcriptional maturation of RNA in human glioblastoma cells, which leads to disruption of the normal course of apoptosis in them. The review thoroughly highlights the latest information on both post-transcriptional modifications of certain regulatory RNAs, associated with the process of apoptosis ...
Anton Dome +3 more
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Influence of Sox protein SUMOylation on neural development and regeneration
Neural Regeneration Research, 2022 SRY-related HMG-box (Sox) transcription factors are known to regulate central nervous system development and are involved in several neurological diseases.
Kun-Che Chang
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Regulation of PD-L1 expression in the tumor microenvironment
Journal of Hematology & Oncology, 2021 Programmed death-ligand 1 (PD-L1) on cancer cells engages with programmed cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple cancer types, the PD-1/PD-L1 axis is the major speed-limiting step of the anti-cancer immune
Ming Yi +4 more
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Biosynthesis and functions of sulfur modifications in tRNA
Frontiers in Genetics, 2014 Sulfur is an essential element for a variety of cellular constituents in all living organisms. In tRNA molecules, there are many sulfur-containing nucleosides, such as the derivatives of 2‑thiouridine (s2U), 4-thiouridine (s4U), 2-thiocytidine (s2C), and
Naoki eShigi
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Role of SUMO-1 modification in transcriptional activation [PDF]
, 2012 In unstimulated cells, the transcription factor NF-κB is held in the cytoplasm in an inactive state by IκB inhibitor proteins. Activation of NF--KB is mediated by signal induced degradation of IκBα via the ubiquitin proteasome-dependent pathway ...
Pinto Desterro, Maria Joana
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