Results 21 to 30 of about 218,971 (253)
Control of Biosynthesis and Post-Transcriptional Modification of the Progesterone Receptor [PDF]
Biology of Reproduction, 1992 The rabbit progesterone receptor undergoes dual regulation at the level of transcription: positive by estrogens and negative by progestins. The two aspects of this regulation are mediated by a single intragenic estrogen-responsive element. Estrogen receptor binding to this element has been demonstrated but progestin down-regulation does not proceed ...
A, Chauchereau +2 more
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Phospho.ELM: A database of experimentally verified phosphorylation sites in eukaryotic proteins
BMC Bioinformatics, 2004 Background Post-translational phosphorylation is one of the most common protein modifications. Phosphoserine, threonine and tyrosine residues play critical roles in the regulation of many cellular processes. The fast growing number of research reports on
Via Allegra +8 more
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Molecular Cancer, 2021 Background The four major RNA adenosine modifications, i.e., m6A, m1A, alternative polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” enzymes and constitute critical mechanisms of epigenetic regulation in immune ...
Huifang Chen +11 more
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The Role of LncRNAs in Translation
Non-Coding RNA, 2021 Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins and regulate gene expression at the transcriptional, post-transcriptional ...
Didem Karakas, Bulent Ozpolat
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The role of cullin4B in human cancers
Experimental Hematology & Oncology, 2017 Cullin 4B (CUL4B) is a scaffold of the Cullin4B-Ring E3 ligase complex (CRL4B) that plays an important role in proteolysis and is implicated in tumorigenesis. Aberrant expression of CUL4B has been reported in various types of human diseases.
Ying Li, Xin Wang
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Cell culture NAIL-MS allows insight into human tRNA and rRNA modification dynamics in vivo
Nature Communications, 2021 Post transcriptional modification of RNAs represents an important layer of gene regulation. Here the authors describe NAIL-MS—a method for monoisotopic RNA labeling in cell culture—demonstrating its capabilities by analyzing the modification kinetics of ...
Matthias Heiss +4 more
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Transcriptome-wide analysis of pseudouridylation in Drosophila melanogaster
G3: Genes, Genomes, Genetics, 2022 Pseudouridine (Psi) is one of the most frequent post-transcriptional modification of RNA. Enzymatic Psi modification occurs on rRNA, snRNA, snoRNA, tRNA, and non-coding RNA and has recently been discovered on mRNA.
Wan Song +3 more
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A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs [PDF]
Nucleic Acids Research, 2014 In mammalian mitochondria, 22 species of tRNAs encoded in mitochondrial DNA play crucial roles in the translation of 13 essential subunits of the respiratory chain complexes involved in oxidative phosphorylation. Following transcription, mitochondrial tRNAs are modified by nuclear-encoded tRNA-modifying enzymes. These modifications are required for the
Suzuki, Takeo, Suzuki, Tsutomu
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Biomarker Research, 2023 N6-methyladenosine (m6A) is considered as the most common and important internal transcript modification in several diseases like type 2 diabetes, schizophrenia and especially cancer.
Jinxin Tang +7 more
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Post-transcriptional modifications to tRNA—a response to the genetic code degeneracy [PDF]
RNA, 2015 We used to think of the genetic code degeneracy as an obligatory process resulting from assigning 61 sense codons to the 20 amino acids in protein. In this degeneracy, 18 of the 20 amino acids are endowed with multiple codons, and the conventional wisdom was that each of the 18 was translated equally from each codon.
Hou, Ya-Ming, Gamper, Howard, Yang, Wei
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