Results 21 to 30 of about 6,379,811 (286)
Expanding the Nucleotide Repertoire of the Ribosome with Post-Transcriptional Modifications [PDF]
ACS Chemical Biology, 2007 In all kingdoms of life, RNAs undergo specific post-transcriptional modifications. More than 100 different analogues of the four standard RNA nucleosides have been identified. Modifications in ribosomal RNAs (rRNAs) are highly prevalent and cluster in regions of the ribosome that have functional importance, have a high level of nucleotide conservation,
Christine S, Chow +2 more
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Phospho.ELM: A database of experimentally verified phosphorylation sites in eukaryotic proteins
BMC Bioinformatics, 2004 Background Post-translational phosphorylation is one of the most common protein modifications. Phosphoserine, threonine and tyrosine residues play critical roles in the regulation of many cellular processes. The fast growing number of research reports on
Via Allegra +8 more
doaj +1 more source
Post-Transcriptional Modification Integration for Ligand-Receptor Cellular Network Inference. [PDF]
Mol Cell ProteomicsCell-cell communications are widely explored to understand tissue homeostasis and diseases. Numerous computational tools have been developed to infer cellular interactions from transcriptomic or proteomic expression data. However, proteins often carry post-translational modifications (PTMs) that can induce conformational switches and alter their ...
Giroux P, Maillard M, Colinge J.
europepmc +4 more sources
Control of Biosynthesis and Post-Transcriptional Modification of the Progesterone Receptor [PDF]
Biology of Reproduction, 1992 The rabbit progesterone receptor undergoes dual regulation at the level of transcription: positive by estrogens and negative by progestins. The two aspects of this regulation are mediated by a single intragenic estrogen-responsive element. Estrogen receptor binding to this element has been demonstrated but progestin down-regulation does not proceed ...
A, Chauchereau +2 more
openaire +2 more sources
Cell Reports, 2016 MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their modest effects on direct targets, together with their participation in larger regulatory networks, make it challenging to delineate miRNA-mediated effects.
Sara J.C. Gosline +9 more
doaj +1 more source
Transcriptional regulation mediated through the conjugation and deconjugation of the small ubiquitin-like modifiers SUMO-1, SUMO-2, and SUMO-3 [PDF]
, 2012 SUMO-1/2/3 are members of the ubiquitin-like family of protein modifiers. These proteins are covalently attached to numerous proteins in a directed and controlled manner.
Girdwood, David William Haxton
core +2 more sources
Molecular Cancer, 2021 Background The four major RNA adenosine modifications, i.e., m6A, m1A, alternative polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” enzymes and constitute critical mechanisms of epigenetic regulation in immune ...
Huifang Chen +11 more
doaj +1 more source
The Role of LncRNAs in Translation
Non-Coding RNA, 2021 Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins and regulate gene expression at the transcriptional, post-transcriptional ...
Didem Karakas, Bulent Ozpolat
doaj +1 more source
Transcriptional and post-transcriptional regulation of ATP-binding cassette transporters.
, 2004 Transcriptional and post-transcriptional regulation of ATP-binding cassette ...
Pui Lai Rachel. Ee (7996370)
core +5 more sources
The role of cullin4B in human cancers
Experimental Hematology & Oncology, 2017 Cullin 4B (CUL4B) is a scaffold of the Cullin4B-Ring E3 ligase complex (CRL4B) that plays an important role in proteolysis and is implicated in tumorigenesis. Aberrant expression of CUL4B has been reported in various types of human diseases.
Ying Li, Xin Wang
doaj +1 more source