Results 51 to 60 of about 571,207 (361)
A role for SUMO modification in transcriptional repression and activation [PDF]
, 2007 Since the discovery of the SUMO (small ubiquitin-like modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
David +26 more
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The role of cullin4B in human cancers
Experimental Hematology & Oncology, 2017 Cullin 4B (CUL4B) is a scaffold of the Cullin4B-Ring E3 ligase complex (CRL4B) that plays an important role in proteolysis and is implicated in tumorigenesis. Aberrant expression of CUL4B has been reported in various types of human diseases.
Ying Li, Xin Wang
doaj +1 more source
Biomarker Research, 2023 N6-methyladenosine (m6A) is considered as the most common and important internal transcript modification in several diseases like type 2 diabetes, schizophrenia and especially cancer.
Jinxin Tang +7 more
doaj +1 more source
Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]
, 2011 Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Arteaga-Salas, Jose M. +6 more
core +3 more sources
Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]
, 2019 Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
Cook, Kate +4 more
core +2 more sources
The genomic landscape of cholangiocarcinoma reveals the disruption of post-transcriptional modifiers
Nature Communications, 2022 Molecular variation between geographical populations and subtypes indicate potential genomic heterogeneity and novel genomic features within CCA. Here, we analyze exome-sequencing data of 87 perihilar cholangiocarcinoma (pCCA) and 261 intrahepatic ...
Y. Zhang +17 more
semanticscholar +1 more source
Small nucleolar RNA‐guided post‐transcriptional modification of cellular RNAs
The EMBO journal, 2001 Tamás Kiss
semanticscholar +3 more sources
Post-transcriptional nucleotide modification and alternative folding of RNA [PDF]
Nucleic Acids Research, 2006 Alternative foldings are an inherent property of RNA and a ubiquitous problem in scientific investigations. To a living organism, alternative foldings can be a blessing or a problem, and so nature has found both, ways to harness this property and ways to avoid the drawbacks.
openaire +3 more sources
Publisher Correction: Post-transcriptional gene regulation by mRNA modifications [PDF]
Nature Reviews Molecular Cell Biology, 2018 In Figure 5, translation initiation is promoted not by the indicated protein, but by YTHDF1 (see below).
Boxuan Simen Zhao +2 more
openaire +1 more source
Nucleic Acids Res., 2022 With advanced technologies to map RNA modifications, our understanding of them has been revolutionized, and they are seen to be far more widespread and important than previously thought.
Yu-xin Zhang +11 more
semanticscholar +1 more source