Results 51 to 60 of about 348,774 (324)

The role of cullin4B in human cancers

Experimental Hematology & Oncology, 2017
Cullin 4B (CUL4B) is a scaffold of the Cullin4B-Ring E3 ligase complex (CRL4B) that plays an important role in proteolysis and is implicated in tumorigenesis. Aberrant expression of CUL4B has been reported in various types of human diseases.
Ying Li, Xin Wang
doaj   +1 more source

Novel insights into the multifaceted roles of m6A-modified LncRNAs in cancers: biological functions and therapeutic applications

Biomarker Research, 2023
N6-methyladenosine (m6A) is considered as the most common and important internal transcript modification in several diseases like type 2 diabetes, schizophrenia and especially cancer.
Jinxin Tang, Jinhui Zhang, Yu Lu, Jieyu He, Hua Wang, Binfeng Liu, Chao Tu, Zhihong Li   +7 more
doaj   +1 more source

Solving the mystery of human sleep schedules one mutation at a time. [PDF]

, 2013
Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui, Hallows, William C, Ptáček, Louis J   +2 more
core   +1 more source

Complex transcriptional and post‐transcriptional regulation of an enzyme for lipopolysaccharide modification [PDF]

Molecular Microbiology, 2013
SummaryThe PhoQ/PhoP two‐component system activates many genes for lipopolysaccharide (LPS) modification when cells are grown at low Mg2+ concentrations. An additional target of PhoQ and PhoP is MgrR, an Hfq‐dependent small RNA that negatively regulates expression of eptB, also encoding a protein that carries out LPS modification.
Susan Gottesman, Hyun-Jung Lee, Christian R. H. Raetz, Kyung Moon, David A. Six   +4 more
openaire   +3 more sources

Recent advances in malaria genomics and epigenomics [PDF]

, 2016
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian, Power, B. Joanne, Waters, Andrew P.   +2 more
core   +1 more source

Modeling cross‐talk of RNA modification enzymes reveals tumor microenvironment‐associated clinical significance and immunotherapy prediction in hepatobiliary malignancy

MedComm, 2023
RNA modification includes four main types, N6‐methyladenosine, N1‐methyladenosine, alternative polyadenylation (APA), and adenosine‐to‐inosine (A‐to‐I) RNA editing, involving 41 enzymes that serve as “writers”, “readers” and “erasers”.
Feng Qi, Jia Li, Zhuoran Qi, Bin Zhou, Biwei Yang, Jun Zhang, Wenxing Qin   +6 more
doaj   +1 more source

Structural landscape of base pairs containing post-transcriptional modifications in RNA [PDF]

RNA, 2017
Base pairs involving post-transcriptionally modified nucleobases are believed to play important roles in a wide variety of functional RNAs. Here we present our attempts toward understanding the structural and functional role of naturally occurring modified base pairs using a combination of X-ray crystal structure database analysis, sequence analysis ...
Preethi P. Seelam, Purshotam Sharma, Abhijit Mitra   +2 more
openaire   +4 more sources

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state [PDF]

, 2016
Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte ...
Alarcon, V, Alvarez, F, De Ferrari, GV, Flores, Y, Hernandez, S, Kann, M, Loyola, A, Rubio, L, Varas-Godoy, M, Villanueva, RA   +9 more
core   +2 more sources

Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice

Nature Communications, 2021
Post-transcriptional modification of RNA can contribute to regulating behavior. Here, the authors show that modulating the expression of Fto results in epitranscriptomic changes in the mouse hippocampus associated with depression-like behavior.
Shu Liu, Jianbo Xiu, Caiyun Zhu, Kexin Meng, Chen Li, Rongrong Han, Tingfu Du, Lanlan Li, Lingdan Xu, Renjie Liu, Wanwan Zhu, Yan Shen, Qi Xu   +12 more
doaj   +1 more source

Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications

Cancers, 2023
Ewing sarcoma is the second most common bone tumor in childhood and adolescence. Currently, first-line therapy includes multidrug chemotherapy with surgery and/or radiation. Although most patients initially respond to chemotherapy, recurrent tumors become treatment refractory.
Le Yu, Ian J. Davis, Pengda Liu
openaire   +2 more sources