Results 101 to 110 of about 694,082 (344)

Functional complementation between transcriptional methylation regulation and post-transcriptional microRNA regulation in the human genome

BMC Genomics, 2011
Background DNA methylation in the 5' promoter regions of genes and microRNA (miRNA) regulation at the 3' untranslated regions (UTRs) are two major epigenetic regulation mechanisms in most eukaryotes. Both DNA methylation and miRNA regulation can suppress
Su Zhixi, Xia Junfeng, Zhao Zhongming
doaj   +1 more source

Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model. [PDF]

PLoS Computational Biology, 2017
Hypoxia is an important physiological stress signal that drives angiogenesis, the formation of new blood vessels. Besides an increase in the production of pro-angiogenic signals such as vascular endothelial growth factor (VEGF), hypoxia also stimulates ...
Chen Zhao, Jeffrey S Isenberg, Aleksander S Popel   +2 more
doaj   +1 more source

Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [PDF]

, 2015
Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors ...
Agrawal, Aitchison, Altschul, Andersson, Blows, Blows, Bonduriansky, Brooks, Chenoweth, Chenoweth, Chung, Connallon, Coyne, Dallerac, Darwin, Doerge, Eyre-Walker, Fang, Ferreira, Ferveur, Fiumera, Frentiu, Gibbs, Gosden, Haldane, Hereford, Hine, Hine, Hine, Howard, Howard, Johnston, Kennington, Kingsolver, Kistler, Labeur, Lande, Long, Magwire, Mousseau, Park, Rako, Reinhart, Ritchie, Roff, Rundle, Sall, Siller, Swanson, Wagner, Weeks, Wilkinson, Zhang   +52 more
core   +4 more sources

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Proteasome- and SCF-dependent degradation of yeast adenine deaminase upon transition from proliferation to quiescence requires a new F-box protein named Saf1p. [PDF]

, 2006
In response to nutrient limitation, Saccharomyces cerevisiae cells enter into a nonproliferating state termed quiescence. This transition is associated with profound changes in gene expression patterns.
Camblong, Jurgi, Daignan-Fornier, Bertrand, Escusa, Stéphanie, Galan, Jean-Marc, Pinson, Benoît   +4 more
core   +3 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

The effects of death and post-mortem cold ischemia on human tissue transcriptomes [PDF]

, 2018
Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA levels.
Aguet, François, Amador, Raziel, Amadoz, Alicia, Ardlie, Kristin G., Breschi, Alessandra, 1988-, Carbonell-Caballero, Jose, Curado, Joao, Dopazo, Joaquín, Ferreira, Pedro G., Godinho, Caio P. Sá, Guigó Serra, Roderic, Hidalgo, Marta R., Muñoz-Aguirre, Manuel, Nurtdinov, Ramil, Oliveira, Carla, Oliveira, Patrícia, Pervouchine, Dmitri D., Reverter, Ferran, Sammeth, Michael, Sodaei, Reza, 1988-, Sousa, Abel, Çubut, Cankut   +21 more
core   +5 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Post-transcriptional regulation of gene expression in Yersinia species

Frontiers in Cellular and Infection Microbiology, 2012
Proper regulation of gene expression is required by bacterial pathogens to respond to continually changing environmental conditions and the host response during the infectious process.
Chelsea A Schiano, Wyndham W Lathem
doaj   +1 more source