Results 81 to 90 of about 774,815 (306)
Role of alternative polyadenylation during adipogenic differentiation: an in silico approach. [PDF]
PLoS ONE, 2013 Post-transcriptional regulation of stem cell differentiation is far from being completely understood. Changes in protein levels are not fully correlated with corresponding changes in mRNAs; the observed differences might be partially explained by post ...
Lucía Spangenberg +3 more
doaj +1 more source
Post-transcriptional regulation of early embryogenesis [PDF]
F1000Prime Reports, 2015 Gene expression is controlled by diverse mechanisms before, during, and after transcription. Chromatin modification factors as well as transcriptional repressors, silencers, and enhancers all feed into how eukaryotes transcribe RNA in the nucleus.
openaire +2 more sources
Post-transcriptional regulation of the pluripotent state [PDF]
Current Opinion in Genetics & Development, 2017 Pluripotency describes the developmental capacity to give rise to all cell types in the adult body. A comprehensive understanding of the molecular mechanisms that regulate pluripotency is important for both basic and translational research. While earlier studies mostly focused on signaling pathways, transcriptional regulation, and epigenetic ...
Qing, Chen, Guang, Hu
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
From the proteomic point of view: Integration of adaptive changes to iron deficiency in plants
Current Plant Biology, 2016 Knowledge about the proteomic adaptations to iron deficiency in plants may contribute to find possible new research targets in order to generate crop plants that are more tolerant to iron deficiency, to increase the iron content or to enhance the ...
Hans-Jörg Mai, Petra Bauer
doaj +1 more source
Proteasome- and SCF-dependent degradation of yeast adenine deaminase upon transition from proliferation to quiescence requires a new F-box protein named Saf1p. [PDF]
, 2006 In response to nutrient limitation, Saccharomyces cerevisiae cells enter into a nonproliferating state termed quiescence. This transition is associated with profound changes in gene expression patterns.
Camblong, Jurgi +4 more
core +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Noise processing by microRNA-mediated circuits: The Incoherent Feed-Forward Loop, revisited [PDF]
, 2016 The intrinsic stochasticity of gene expression is usually mitigated in higher eukaryotes by post-transcriptional regulation channels that stabilise the output layer, most notably protein levels. The discovery of small non-coding RNAs (miRNAs) in specific
De Martino, Andrea +3 more
core +2 more sources
Post-transcriptional regulation of rat carnitine octanoyltransferase
Biochemical Society Transactions, 2001 Carnitine octanoyltransferase (COT) produces three different transcripts in rat through cis- and trans-splicing reactions, which can lead to the synthesis of two proteins. The occurrence of the three COT transcripts in rat has been found in all tissues examined and does not depend on sex, fat feeding, peroxisome proliferators or hyperinsulinaemia.
Hegardt, Fausto G. +6 more
openaire +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source