Results 31 to 40 of about 416,495 (263)
Post-translational regulation of Oct4 transcriptional activity.
PLoS ONE, 2009 Oct4 is a key component of the molecular circuitry which regulates embryonic stem cell proliferation and differentiation. It is essential for maintenance of undifferentiated, pluripotent cell populations, and accomplishes these tasks by binding DNA in ...
Jonathan P Saxe +4 more
doaj +1 more source
Research progress on post-transcriptional dysregulation of mRNA in pathogenesis of Alzheimer's disease [PDF]
Jichu yixue yu linchuang, 2021 Post-transcriptional regulation of mRNA is an essential step from RNA transcription to gene translation, the process includes mRNA splicing, nuclear export, translation, and decay.
SUN Jing-yao, TONG Wei-min, NIU Ya-mei
doaj
Stress Granules in the Post-transcriptional Regulation of Immune Cells
Frontiers in Cell and Developmental Biology, 2021 Immune cell activation triggers transcriptional and translational programs eliciting cellular processes, such as differentiation or proliferation, essential for an efficient immune response.
Nicolas Curdy +18 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Transcriptional and Post-transcriptional Regulation of Lignin Biosynthesis Pathway Genes in Populus
Frontiers in Plant Science, 2020 Lignin is a heterogeneous polymer of aromatic subunits derived from phenylalanine. It is polymerized in intimate proximity to the polysaccharide components in plant cell walls and provides additional rigidity and compressive strength for plants ...
Jin Zhang +9 more
doaj +1 more source
Role of alternative polyadenylation during adipogenic differentiation: an in silico approach. [PDF]
PLoS ONE, 2013 Post-transcriptional regulation of stem cell differentiation is far from being completely understood. Changes in protein levels are not fully correlated with corresponding changes in mRNAs; the observed differences might be partially explained by post ...
Lucía Spangenberg +3 more
doaj +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Post-transcriptional control of fungal cell wall synthesis
The Cell Surface, 2022 Pathogenic fungi hide from their hosts by camouflage, obscuring immunogenic cell wall components such as beta-glucan with innocuous coverings such as mannoproteins and alpha-glucan that are less readily recognised by the host.
Rebecca A. Hall, Edward W.J. Wallace
doaj
The role of long non-coding RNAs in genome formatting and expression
Frontiers in Genetics, 2015 Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential but having a pivotal role in numerous biological functions. Long non-coding RNAs act as regulators at different levels of gene expression including chromatin organization ...
Pierre-Olivier eAngrand +3 more
doaj +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source